Phosphine oxide, [2-(8-methylene-1,4-dioxaspiro[4.5]dec-7-ylidene)ethyl]diphenyl-, (E)-

Base Information

Chemical Name:Phosphine oxide, [2-(8-methylene-1,4-dioxaspiro[4.5]dec-7-ylidene)ethyl]diphenyl-, (E)-
CAS No.:88790-49-2
Molecular Formula:C23H25O3P
Molecular Weight:380.423
Hs Code.:

Synonyms:

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Chemical Property of Phosphine oxide, [2-(8-methylene-1,4-dioxaspiro[4.5]dec-7-ylidene)ethyl]diphenyl-, (E)-

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Technology Process of Phosphine oxide, [2-(8-methylene-1,4-dioxaspiro[4.5]dec-7-ylidene)ethyl]diphenyl-, (E)-

There total 4 articles about Phosphine oxide, [2-(8-methylene-1,4-dioxaspiro[4.5]dec-7-ylidene)ethyl]diphenyl-, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 86791-92-6
4,4-(ethylenedioxy)-7-diphenylphosphinoylmethylbicyclo<4.2.0>octa-1(6)-ene

: 88790-49-2
7-[2-(Diphenyl-phosphinoyl)-eth-(E)-ylidene]-8-methylene-1,4-dioxa-spiro[4.5]decane

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; -78 deg C, 15 min then -20 deg C, 16 h;
DOI:10.1016/S0040-4020(01)91875-7

Reference yield:

: 30118-28-6
5-methoxybenzocyclobutenylmethanol

: 88790-49-2
7-[2-(Diphenyl-phosphinoyl)-eth-(E)-ylidene]-8-methylene-1,4-dioxa-spiro[4.5]decane

Guidance literature:: Multi-step reaction with 5 steps

1: 1) EtOH, Na, liq.NH₃ 2) toluene-p-sulfonic acid / 1) THF, -78 deg C 2) CH₂Cl₂, r.t., 1 h

2: pyridine / 1 h / Ambient temperature

3: NaBr / dimethylformamide / 2 h / 80 - 85 °C

4: 2) 5 percent hydrogen peroxide / 1) THF, -20 deg C, 10 min 2) CHCl₃, room temperature, 30 min

5: 76 percent / lithium diisopropylamide / tetrahydrofuran / -78 deg C, 15 min then -20 deg C, 16 h

With pyridine; ethanol; ammonia; dihydrogen peroxide; sodium; toluene-4-sulfonic acid; sodium bromide; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)91875-7

Reference yield:

: 86791-85-7
C₁₈H₂₂O₅S

: 88790-49-2
7-[2-(Diphenyl-phosphinoyl)-eth-(E)-ylidene]-8-methylene-1,4-dioxa-spiro[4.5]decane

Guidance literature:: Multi-step reaction with 3 steps

1: NaBr / dimethylformamide / 2 h / 80 - 85 °C

2: 2) 5 percent hydrogen peroxide / 1) THF, -20 deg C, 10 min 2) CHCl₃, room temperature, 30 min

3: 76 percent / lithium diisopropylamide / tetrahydrofuran / -78 deg C, 15 min then -20 deg C, 16 h

With dihydrogen peroxide; sodium bromide; lithium diisopropyl amide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)91875-7