6,7-Dichloro-2-ethyl-1-oxo-5-indanyloxyacetic acid

Base Information

Chemical Name:6,7-Dichloro-2-ethyl-1-oxo-5-indanyloxyacetic acid
CAS No.:27366-21-8
Molecular Formula:C₁₃H₁₂Cl₂O₄
Molecular Weight:303.142
Hs Code.:2918990090
DSSTox Substance ID:DTXSID90950065
Nikkaji Number:J54.197D
ChEMBL ID:CHEMBL3278173
Mol file:27366-21-8.mol

Synonyms:BRN 1887508;27366-21-8;6,7-Dichloro-2-ethyl-1-oxo-5-indanyloxyacetic acid;ACETIC ACID, 6,7-DICHLORO-2-ETHYL-1-OXO-5-INDANYLOXY-;CHEMBL3278173;SCHEMBL11112682;DTXSID90950065;SZOLGWAHEZEMMN-UHFFFAOYSA-N;(1-oxo-2-ethyl-6,7-dichloro-5-indanyloxy)-acetic acid;(1-oxo-2-ethyl-6,7-dichloro-5-indanyloxy)acetic acid;[(6,7-Dichloro-2-ethyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy]acetic acid;[(6,7-Dichloro-2-ethyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]acetic acid;Acetic acid, [(6,7-dichloro-2-ethyl-2,3-dihydro-1-oxo-1H-inden-5-yl)oxy]-

Suppliers and Price of 6,7-Dichloro-2-ethyl-1-oxo-5-indanyloxyacetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 6,7-Dichloro-2-ethyl-1-oxo-5-indanyloxyacetic acid

Chemical Property:

Vapor Pressure:4.95E-11mmHg at 25°C
Melting Point:169-171 °C(Solv: acetonitrile (75-05-8))
Boiling Point:505.3°C at 760 mmHg
PKA:2.80±0.10(Predicted)
Flash Point:259.4°C
PSA：63.60000
Density:1.432g/cm³
LogP:3.22180
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:302.0112642
Heavy Atom Count:19
Complexity:374

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCC1CC2=CC(=C(C(=C2C1=O)Cl)Cl)OCC(=O)O

Technology Process of 6,7-Dichloro-2-ethyl-1-oxo-5-indanyloxyacetic acid

There total 2 articles about 6,7-Dichloro-2-ethyl-1-oxo-5-indanyloxyacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 58-54-8
ethacrynic acid

: 27366-21-8
(6,7-Dichlor-2-ethyl-1-oxo-5-indanyloxy)-essigsaeure

Guidance literature:: With PPA; at 100 ℃; for 3h;
DOI:10.1002/ardp.19813140207

Reference yield:

: 27366-21-8
(6,7-Dichlor-2-ethyl-1-oxo-5-indanyloxy)-essigsaeure

Guidance literature:: /BRN= 915060/, conc.H2SO4;
DOI:10.1021/jm00221a010

Reference yield:

: 27366-21-8
(6,7-Dichlor-2-ethyl-1-oxo-5-indanyloxy)-essigsaeure

: 81997-19-5
benzyloxycarbonylmethyl [(5,6-dichloro-9a-ethyl-3-oxo-1,2,9,9a-tetrahydro-3H-fluoren-7-yl)oxy]-acetate

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / conc. H₂SO₄ / 2 h / Heating

2: 78 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / tetrahydrofuran / 16 h / Ambient temperature

3: 57 percent / aq. NaOH / ethanol / 48 h / 25 °C

4: K₂CO₃ / dimethylformamide

With sodium hydroxide; sulfuric acid; DBN; potassium carbonate; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;
DOI:10.1021/jm00155a038