Technology Process of Cyclopent[b]indole-3-carboxylic acid,
1,2,3,4-tetrahydro-3-methyl-4-[(4-methylphenyl)sulfonyl]-2-oxo-, methyl
ester
There total 8 articles about Cyclopent[b]indole-3-carboxylic acid,
1,2,3,4-tetrahydro-3-methyl-4-[(4-methylphenyl)sulfonyl]-2-oxo-, methyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 93 percent / MeLi, HCl, Et3N / diethyl ether / 1 h / 0 °C
2: 95 percent / Et3N / CH2Cl2 / 48 h / 20 °C
3: 97 percent / NaBH4, NH4Cl / tetrahydrofuran; methanol / 0.08 h / 20 °C
4: 72 percent / 2,4,6-trimethyl benzoic acid / 3 h / 185 °C / Heating
5: 93 percent / Br2 / CH2Cl2 / 0.08 h / -78 °C
6: 99 percent / ethyl aluminum dichloride / hexane; hexamethylphosphoric acid triamide / 24 h / 20 °C
7: 47 percent / toluene / 21 h / 110 °C / Heating
With
hydrogenchloride; sodium tetrahydroborate; mesitylenecarboxylic acid; methyllithium; bromine; ethylaluminum dichloride; ammonium chloride; triethylamine;
In
tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; hexane; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)88613-0
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 93 percent / Br2 / CH2Cl2 / 0.08 h / -78 °C
2: 99 percent / ethyl aluminum dichloride / hexane; hexamethylphosphoric acid triamide / 24 h / 20 °C
3: 47 percent / toluene / 21 h / 110 °C / Heating
With
bromine; ethylaluminum dichloride;
In
N,N,N,N,N,N-hexamethylphosphoric triamide; hexane; dichloromethane; toluene;
DOI:10.1016/S0040-4020(01)88613-0
