Pyrrolo[1,2-b]pyridazin-4...

Base Information

• Chemical Name: Pyrrolo[1,2-b]pyridazin-4...
• CAS No.: 888720-26-1
• Molecular Formula: C7H6N2O
• Molecular Weight: 134.13500
• Hs Code.: 2933990090
• Mol file: 888720-26-1.mol

Synonyms:1H-pyrrolo[1,2-b]pyridazin-4-one;

Chemical Property of Pyrrolo[1,2-b]pyridazin-4...

Chemical Property:

• Vapor Pressure: 0.022mmHg at 25°C
• Boiling Point: 250.499oC at 760 mmHg
• PKA: 4.23±0.30(Predicted)
• Flash Point: 105.298oC
• PSA: 37.27000
• Density: 1.331g/cm3
• LogP: 0.62760
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%,99%, ^*data from raw suppliers

Pyrrolo[1,2-B]pyridazin-4(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Pyrrolo[1,2-b]pyridazin-4...

There total 3 articles about Pyrrolo[1,2-b]pyridazin-4... which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1,4-dihydro-4-oxopyrrolo<1,2-b>pyridazine-3-carboxylic acid (156335-30-7) → pyrrolo[1,2-b]pyridazin-4(1H)-one (888720-26-1)

Guidance literature:

In dimethyl sulfoxide; at 150 ℃; for 1h;

Reference yield:

ethyl 1,4-dihydro-4-oxopyrrolo<1,2-b>pyridazine-3-carboxylate (156335-37-4) → pyrrolo[1,2-b]pyridazin-4(1H)-one (888720-26-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide; water / ethanol / 100 °C

1.2: pH 2

2.1: dimethyl sulfoxide / 1 h / 150 °C

With water; sodium hydroxide; In ethanol; dimethyl sulfoxide;

Reference yield:

diethyl (1-pyrrolyl)aminomethylenepropanedioate (156335-36-3) → pyrrolo[1,2-b]pyridazin-4(1H)-one (888720-26-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: diphenylether / 2 h / 220 °C / Inert atmosphere

2.1: sodium hydroxide; water / ethanol / 100 °C

2.2: pH 2

3.1: dimethyl sulfoxide / 1 h / 150 °C

With water; sodium hydroxide; In diphenylether; ethanol; dimethyl sulfoxide;

upstream raw materials:

ethyl 1,4-dihydro-4-oxopyrrolo<1,2-b>pyridazine-3-carboxylate

1,4-dihydro-4-oxopyrrolo<1,2-b>pyridazine-3-carboxylic acid

diethyl (1-pyrrolyl)aminomethylenepropanedioate

Downstream raw materials:

4-(4-nitrophenoxy)-pyrrolo[1,2-b]pyridazine

N-(4-(5-bromopyrrolo[1,2-b]pyridazin-4-yloxy)-3-fluorophenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide

4-(2-fluoro-4-nitrophenoxy)pyrrolo[1,2-b]pyridazine

5-bromo-4-(2-fluoro-4-nitrophenoxy)pyrrolo[1,2-b]pyridazine

Refernces

• 1、 -. "HETEROCYCLIC COMPOUND AS PROTEIN KINASE INHIBITOR". . . Retrieved 2011/08/06.