L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 5-hexadecyl 1-(phenylmethyl) ester

Base Information

• Chemical Name: L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 5-hexadecyl 1-(phenylmethyl) ester
• CAS No.: 88887-49-4
• Molecular Formula: C33H55NO6
• Molecular Weight: 561.803
• Mol file: 88887-49-4.mol

Synonyms:

Chemical Property of L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 5-hexadecyl 1-(phenylmethyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 5-hexadecyl 1-(phenylmethyl) ester

There total 2 articles about L-Glutamic acid, N-[(1,1-dimethylethoxy)carbonyl]-, 5-hexadecyl 1-(phenylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-Hexadecanol (36653-82-4,124-29-8) + Boc-Glu-OBn (30924-93-7) → α-benzyl γ-n-hexadecyl N-(tert-butyloxycarbonyl)-L-glutamate (88887-49-4)

Guidance literature:

With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.chemphyslip.2008.11.005

Reference yield: 96.0%

Boc-Glu-OBn (30924-93-7) + hexadecanyl bromide (112-82-3) → α-benzyl γ-n-hexadecyl N-(tert-butyloxycarbonyl)-L-glutamate (88887-49-4)

Guidance literature:

With Cs₂CO₂; In N,N-dimethyl-formamide; for 60h; Ambient temperature;

DOI:10.1021/jm00371a009

Reference yield:

α-benzyl γ-n-hexadecyl N-(tert-butyloxycarbonyl)-L-glutamate (88887-49-4) → C28H47NO4 (1174027-16-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.5h; Cooling with ice;

DOI:10.1016/j.chemphyslip.2008.11.005

upstream raw materials:

Boc-Glu-OBn

hexadecanyl bromide

1-Hexadecanol

Downstream raw materials:

C₂₈H₄₇NO₄