mappicine

Base Information

• Chemical Name: mappicine
• CAS No.: 54318-59-1
• Molecular Formula: C₁₉H₁₈N₂O₂
• Molecular Weight: 306.364
• Mol file: 54318-59-1.mol

Synonyms:Indolizino[1,2-b]quinolin-9(11H)-one,7-(1-hydroxypropyl)-8-methyl-, (S)-; (-)-Mappicine; (S)-Mappicine; Mappicine

Chemical Property of mappicine

Chemical Property:

• Vapor Pressure: 4.97E-16mmHg at 25°C
• Boiling Point: 616°C at 760 mmHg
• Flash Point: 326.3°C
• PSA: 55.12000
• Density: 1.33g/cm³
• LogP: 3.17700

Purity/Quality:

98.5% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: Mappia foetida contains this alkaloid which is a minor constituent of the alkaloidal extract. The base has been partially synthesized from camptothecin.

Technology Process of mappicine

There total 26 articles about mappicine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(S)-mappicine acetate (54318-60-4) → (S)-mappicine (54318-59-1)

Guidance literature:

With potassium carbonate; In methanol; for 2h; Heating;

DOI:10.1016/S0040-4020(99)00397-X

Reference yield: 74.0%

7-{1-[(3,3,4,4,5,5,6,6,7,7,8,8,9,9,10,10,10-heptadecafluoro-decyl)-diisopropyl-silanyloxy]-propyl}-8-methyl-11H-indolizino[1,2-b]quinolin-9-one (340128-80-5) → (S)-mappicine (54318-59-1)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;

DOI:10.1021/ja025606x

Reference yield: 73.0%

8-methyl-7-propionylindolizino[1,2-b]quinoline-9(11H)-one (55854-89-2) → (S)-mappicine (54318-59-1)

Guidance literature:

With (-)-(S)-BINAL-H; In tetrahydrofuran; at -78 ℃; for 16h;

DOI:10.1021/ja973007y

upstream raw materials:

phenyl isocyanate

6-Bromo-4-((S)-1-hydroxy-propyl)-3-methyl-1-prop-2-ynyl-1H-pyridin-2-one

8-methyl-7-propionylindolizino[1,2-b]quinoline-9(11H)-one

7-(1-acetoxy-propyl)-8-methyl-11H-indolizino[1,2-b]quinolin-9-one

Downstream raw materials:

8-methyl-7-propionylindolizino[1,2-b]quinoline-9(11H)-one