MAPPICINE KETONE

Base Information

• Chemical Name: MAPPICINE KETONE
• CAS No.: 55854-89-2
• Molecular Formula: C19H16 N2 O2
• Molecular Weight: 304.348
• Mol file: 55854-89-2.mol

Synonyms:Mappicineketone; Nothapodytine B

Chemical Property of MAPPICINE KETONE

Chemical Property:

• Vapor Pressure: 5.68E-14mmHg at 25°C
• Boiling Point: 591.7°Cat760mmHg
• Flash Point: 311.6°C
• PSA: 51.96000
• Density: 1.32g/cm³
• LogP: 3.32630

Purity/Quality:

95% ^*data from raw suppliers

MAPPICINE KETONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of MAPPICINE KETONE

There total 101 articles about MAPPICINE KETONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

camptothecin (7689-03-4,91926-09-9) → 8-methyl-7-propionylindolizino[1,2-b]quinoline-9(11H)-one (55854-89-2)

Guidance literature:

With boron trifluoride diethyl etherate; for 0.116667h; Ambient temperature; microwave irradiation;

DOI:10.1016/S0040-4039(97)10539-1

Reference yield: 85.0%

(S)-mappicine (54318-59-1) → 8-methyl-7-propionylindolizino[1,2-b]quinoline-9(11H)-one (55854-89-2)

Guidance literature:

With Celite; pyridinium chlorochromate; In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4020(97)90398-7

Reference yield: 76.0%

7-(1-ethyl-vinyl)-8-methyl-11H-indolizino[1,2-b]quinolin-9-one (717127-93-0) → 8-methyl-7-propionylindolizino[1,2-b]quinoline-9(11H)-one (55854-89-2)

Guidance literature:

With 2,3-dimercapto-succinic acid; ozone; In dichloromethane;

DOI:10.1016/j.tetlet.2004.03.089

upstream raw materials:

camptothecin

1-(2-Bromo-quinolin-3-ylmethyl)-3-methyl-4-propionyl-1H-pyridin-2-one

(S)-mappicine

1-[2-Methoxy-6-(3-methoxymethyl-quinolin-2-yl)-3-methyl-pyridin-4-yl]-propan-1-one

Downstream raw materials:

(S)-mappicine

5-benzoyloxymappicine ketone