N-(2,4-dichloro-5-hydroxyphenyl)acetamide

Base Information

• Chemical Name: N-(2,4-dichloro-5-hydroxyphenyl)acetamide
• CAS No.: 67669-19-6
• Molecular Formula: C8H7Cl2NO2
• Molecular Weight: 220.055
• Hs Code.: 2924299090
• European Community (EC) Number: 429-110-0,622-127-6
• UNII: RD62AQN79F
• DSSTox Substance ID: DTXSID80371068
• Wikidata: Q82158303
• Mol file: 67669-19-6.mol

Synonyms:N-(2,4-dichloro-5-hydroxyphenyl)acetamide;67669-19-6;2,4-Dichloro-5-hydroxyacetanilide;2',4'-Dichloro-5'-hydroxyacetanilide;EC 429-110-0;Acetamide, N-(2,4-dichloro-5-hydroxyphenyl)-;RD62AQN79F;SCHEMBL7076639;4,6-dichloro-3-acetaminophenol;DTXSID80371068;5-Acetylamino-2,4-dichlorophenol;KKTTWHOBHAIWDY-UHFFFAOYSA-N;MFCD00186236;AKOS005070475;4L-304S;CS-W014260;SB80380;FT-0680370;2',4'-Dichloro-5'-hydroxyacetanilide, 97%;N-(2,4-Dichloro-5-Hydroxyphenyl)-Acetamide;D94762;A867211;J-522817

Chemical Property of N-(2,4-dichloro-5-hydroxyphenyl)acetamide

Chemical Property:

• Appearance/Colour: White to tan powder, crystals or crystalline powder and/or chunks
• Vapor Pressure: 8.67E-07mmHg at 25°C
• Melting Point: 233-236 °C
• Refractive Index: 1.64
• Boiling Point: 394.5 °C at 760 mmHg
• Flash Point: 192.4 °C
• PSA: 49.33000
• Density: 1.519 g/cm³
• LogP: 2.73040
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 218.9853839
• Heavy Atom Count: 13
• Complexity: 201

Purity/Quality:

99.9% ^*data from raw suppliers

N-(2,4-Dichloro-5-hydroxyphenyl)acetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T,Xi
• Hazard Codes: T,Xi
• Statements: 25-36/37/38
• Safety Statements: 26-36-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(=O)NC1=CC(=C(C=C1Cl)Cl)O

Technology Process of N-(2,4-dichloro-5-hydroxyphenyl)acetamide

There total 6 articles about N-(2,4-dichloro-5-hydroxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

meta-hydroxyacetanilide (621-42-1) → N-(2,4-dichloro-5-hydroxyphenyl)acetamide (67669-19-6)

Guidance literature:

With sulfuryl dichloride; In chloroform; at 40 ℃; for 3h; Temperature; Solvent;

Reference yield:

ammonium acetate (631-61-8,92206-38-7) + m-Hydroxyaniline (591-27-5) → N-(2,4-dichloro-5-hydroxyphenyl)acetamide (67669-19-6)

Guidance literature:

ammonium acetate; m-Hydroxyaniline; With acetic acid; for 3h; Reflux;

With sulfuryl dichloride; at 20 - 25 ℃; for 4h;

Reference yield:

meta-hydroxyacetanilide (621-42-1) → acetic acid-(2,4,6-trichloro-3-hydroxy-anilide) (7397-28-6) + N-(2,4-dichloro-5-hydroxyphenyl)acetamide (67669-19-6)

Guidance literature:

With chlorine; acetic acid; at 15 - 20 ℃;

upstream raw materials:

meta-hydroxyacetanilide

chlorine

acetic acid

acetic anhydride

Downstream raw materials:

4,6-dichloro-1-hydroxy-3-aminobenzene

N-(2,4-dichloro-5-methoxybenzene)acetamide

4,6-dichloro-3-ethoxyacetanilide

5-n-Propoxy-2,4-dichloracetanilid

Refernces

• 1、 -. "A method for synthesizing intermediate oxadiazon". Paragraph 0063; 0087; 0094-0098; 0110; 0115-0119; 0132. . Retrieved 2019/07/04.
• 2、 Mao, Yongjun,Zhu, Chunping,Kong, Ziyang,Wang, Jiao,Zhu, Guoqing,Ren, Xinfeng. "New Synthetic Process for Bosutinib". . p. 3133 - 3138. Retrieved 2015/10/19.