Acetic Acid

Base Information

• Chemical Name: Acetic Acid
• CAS No.: 64-19-7
• Deprecated CAS: 77671-22-8,1053656-97-5,1173022-32-6,1053656-97-5
• Molecular Formula: C2H4O2
• Molecular Weight: 60.0526
• Hs Code.: 29152100
• European Community (EC) Number: 200-580-7,616-485-2,633-465-9,685-234-7
• ICSC Number: 0363
• NSC Number: 406306,132953
• UN Number: 2789,2790
• UNII: Q40Q9N063P
• DSSTox Substance ID: DTXSID5024394
• Nikkaji Number: J2.355H
• Wikipedia: Acetic acid,Acetic_acid,Orthoacetic_acid
• Wikidata: Q47512
• NCI Thesaurus Code: C61623
• RXCUI: 168
• Metabolomics Workbench ID: 24
• ChEMBL ID: CHEMBL539
• Mol file: 64-19-7.mol

Synonyms:Acetic Acid;Acetic Acid Glacial;Acetic Acid, Glacial;Glacial Acetic Acid;Glacial, Acetic Acid;Vinegar

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Chemical Property of Acetic Acid

Chemical Property:

• Appearance/Colour: Clear colorless liquid
• Melting Point: 16-16.5 °C
• Refractive Index: n20/D 1.371(lit.)
• Boiling Point: 117.065 °C at 760 mmHg
• PKA: 4.79±0.10(Predicted)
• Flash Point: 40 °C
• PSA: 37.30000
• Density: 1.069 g/cm³
• LogP: 0.09090
• Water Solubility.: miscible
• XLogP3: -0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 60.021129366
• Heavy Atom Count: 4
• Complexity: 31

Purity/Quality:

Safty Information:

• Pictogram(s): C,Xi
• Hazard Codes: C:Corrosive
• Statements: R10:; R35:
• Safety Statements: S23:; S26:; S45:

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Other Classes -> Organic Acids
• Canonical SMILES: CC(=O)O
• Recent ClinicalTrials: Daily Vinegar Ingestion and Metabolic Health
• Recent EU Clinical Trials: A pilot randomised controlled trial to examine the efficacy and optimal dose of Acetic Acid to treat colonised burns wounds.
• Recent NIPH Clinical Trials: Comparison of magnifying endoscopy with narrow band imaging (ME-NBI) attached balloon versus colposcopy for diagnosing cervical cancer, including acceptability of the endoscope: An exploratory prospective study
• Inhalation Risk: A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.
• Effects of Short Term Exposure: The substance is corrosive to the eyes, skin and respiratory tract. Corrosive on ingestion. Inhalation may cause lung oedema, but only after initial corrosive effects on eyes and/or airways have become manifest.
• Effects of Long Term Exposure: Repeated or prolonged contact with skin may cause dermatitis. Lungs may be affected by repeated or prolongated exposure to an aerosol of this substance. Risk of tooth erosion upon repeated or prolongated exposure to an aerosol of this substance.

Technology Process of Acetic Acid

There total 4275 articles about Acetic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

p-cresol (106-44-5) → 4-methyl-2-nitrophenol (119-33-5) + 2,6-dinitro-p-cresol (609-93-8) + acetic acid (64-19-7,77671-22-8) + propionic acid (802294-64-0,79-09-4)

Guidance literature:

beim Nitrieren;

Reference yield:

6-methoxy-3-methyl-hept-2-en-4-one (103263-50-9) + chloroform (67-66-3,8013-54-5) → 3-methoxybutanoic acid (10024-70-1,16510-79-5) + acetic acid (64-19-7,77671-22-8)

Guidance literature:

bei der Ozonolyse;

Reference yield:

heptadecan-2-one (2922-51-2) → palmitic acid (1002-84-2) + acetic acid (64-19-7,77671-22-8)

Guidance literature:

With chromic acid;

upstream raw materials:

thiophene

chloroform

diacetyl peroxide

2-methyl-1,3-dioxolane

Downstream raw materials:

1-(2-hydroxyethylamino)anthracene-9,10-dione

1,4-bis-(2-hydroxyethylamino)anthraquinone

2-hydroxyethyl acetate

ethylene glycol diacetate

Refernces

• 1、 Neogi,Chowdhuri. "-". . p. 701. Retrieved 1916.
• 2、 Wiseman, Floyd Landis. "New insight on an old reaction - The aqueous hydrolysis of acetic anhydride". . p. 1105 - 1111. Retrieved 2012.
• 3、 Choi, Sang-Il,Han, Yeji,Hong, Jong Wook,Kim, Jeonghyeon,Lee, Su-Un. "Synthesis of Pd-Pt Ultrathin Assembled Nanosheets as Highly Efficient Electrocatalysts for Ethanol Oxidation". . . Retrieved 2020.
• 4、 Teng, Yuxiang,Guo, Ke,Fan, Dongping,Guo, Hongyou,Han, Min,Xu, Dongdong,Bao, Jianchun. "Rapid Aqueous Synthesis of Large-Size and Edge/Defect-Rich Porous Pd and Pd-Alloyed Nanomesh for Electrocatalytic Ethanol Oxidation". . p. 11175 - 11182. Retrieved 2021.
• 5、 Xu, Ling,Boring, Eric,Hill, Craig L.. "Polyoxometalate-Modified Fabrics: New Catalytic Materials for Low-Temperature Aerobic Oxidation". . p. 394 - 405. Retrieved 2000.
• 6、 Lugo-González, José Carlos,Gómez-Tagle, Paola,Huang, Xiaomin,M. Del Campo, Jorge,Yatsimirsky, Anatoly K.. "Substrate Specificity and Leaving Group Effect in Ester Cleavage by Metal Complexes of an Oximate Nucleophile". . p. 2060 - 2069. Retrieved 2017.
• 7、 Park, Kwangho,Lim, Sangyup,Baik, Joon Hyun,Kim, Honggon,Jung, Kwang-Deog,Yoon, Sungho. "Exceptionally stable Rh-based molecular catalyst heterogenized on a cationically charged covalent triazine framework support for efficient methanol carbonylation". . p. 2894 - 2900. Retrieved 2018.
• 8、 Rubtsov, Yu. I.,Kazakov,Sorokina,Manelis. "Critical phenomena in acetone oxidation by nitric acid". . p. 2065 - 2071. Retrieved 2008.
• 9、 Lyu, Shuting,Wang, Tiefeng. "Efficient production of acrylic acid by dehydration of lactic acid over BaSO4 with crystal defects". . p. 10278 - 10286. Retrieved 2017.
• 10、 Kirillov, Alexander M.,Haukka, Matti,Kirillova, Marina V.,Pombeiro, Armando J. L.. "Single-pot ethane carboxylation catalyzed by new oxorhenium(V) complexes with N,O ligands". . p. 1435 - 1446. Retrieved 2005.