1H-Azepine-1-propanoic acid, hexahydro-2-oxo-, ethyl ester

Base Information

• Chemical Name: 1H-Azepine-1-propanoic acid, hexahydro-2-oxo-, ethyl ester
• CAS No.: 88948-41-8
• Molecular Formula: C11H19NO3
• Molecular Weight: 213.27300
• Mol file: 88948-41-8.mol

Synonyms:

Chemical Property of 1H-Azepine-1-propanoic acid, hexahydro-2-oxo-, ethyl ester

Chemical Property:

• PSA: 46.61000
• LogP: 1.28010

Purity/Quality:

98%min ^*data from raw suppliers

Ethyl 3-(2-oxoazepan-1-yl)propanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Azepine-1-propanoic acid, hexahydro-2-oxo-, ethyl ester

There total 2 articles about 1H-Azepine-1-propanoic acid, hexahydro-2-oxo-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

caprolactam (105-60-2,9012-16-2) + ethyl acrylate (140-88-5,9003-32-1) → 3-(2-Oxo-azepan-1-yl)-propionic acid ethyl ester (88948-41-8)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran;

DOI:10.1055/s-2002-20951

Reference yield:

caprolactam (105-60-2,9012-16-2) + Ethyl 3-bromopropionate (539-74-2) → 3-(2-Oxo-azepan-1-yl)-propionic acid ethyl ester (88948-41-8)

Guidance literature:

With sodium hydride; Yield given. Multistep reaction; 1.) benzene, room temp., 2.) benzene;

DOI:10.1007/BF00765967

Reference yield: 85.0%

3-(2-Oxo-azepan-1-yl)-propionic acid ethyl ester (88948-41-8) → N-Hydrazinocarbonylmethylcaprolactam (88948-38-3)

Guidance literature:

With hydrazine hydrate; In isopropyl alcohol; for 4h; Heating;

DOI:10.1007/BF00765967

upstream raw materials:

caprolactam

Ethyl 3-bromopropionate

ethyl acrylate

Downstream raw materials:

N-Hydrazinocarbonylmethylcaprolactam

Refernces

• 1、 Muthusamy, Sengodagounder,Gunanathan, Chidambaram,Babu, Srinivasarao Arulananda. "Rhodium(II) acetate catalyzed synthesis of cyclic enamides and enamines via β-hydride elimination". . p. 471 - 474. Retrieved 2007/10/03.