2-(3-Hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethan-1-one

Base Information

Chemical Name:2-(3-Hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethan-1-one
CAS No.:89018-72-4
Molecular Formula:C18H20O6
Molecular Weight:332.353
Hs Code.:
DSSTox Substance ID:DTXSID80555922
Wikidata:Q82437380

Synonyms:89018-72-4;DTXSID80555922;2-(3-Hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethan-1-one

Suppliers and Price of 2-(3-Hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-(3-Hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethan-1-one

Chemical Property:

XLogP3:2.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:7
Exact Mass:332.12598835
Heavy Atom Count:24
Complexity:387

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(C=C(C=C1)CC(=O)C2=CC(=C(C(=C2)OC)OC)OC)O

Technology Process of 2-(3-Hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethan-1-one

There total 20 articles about 2-(3-Hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 105485-74-3
2-[4-methoxy-3-(phenylmethoxy)phenyl]-1-(3,4,5-trimethoxyphenyl)-ethanone

: 89018-72-4
2-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethan-1-one

Guidance literature:: With ammonium formate; palladium on activated charcoal; In methanol; for 1h; Heating;

Reference yield: 95.0%

: 1127352-16-2
2-(3-((tert-butyldimethylsilyl)oxy)-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethan-1-one

: 89018-72-4
2-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethan-1-one

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h;
DOI:10.3390/ijms21051817

Reference yield:

: 86-81-7
3,4,5-trimethoxy-benzaldehyde

: 89018-72-4
2-(3-hydroxy-4-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)ethan-1-one

Guidance literature:: Multi-step reaction with 5 steps

1: 79 percent / n-Bu₂NH / diethyl ether / 3 h / 20 °C

2: TsOH / benzene / 0.5 h / 50 °C

3: NaH / ethanol / 18 h / 20 °C

4: aq. HCl / methanol / 1 h / 20 °C

5: H₂ / Pd/C / 2 h / 20 °C

With hydrogenchloride; hydrogen; sodium hydride; toluene-4-sulfonic acid; dibutylamine; palladium on activated charcoal; In methanol; diethyl ether; ethanol; benzene;
DOI:10.1016/j.bmcl.2006.11.060