17-(phenylseleno)progesterone

Base Information

• Chemical Name: 17-(phenylseleno)progesterone
• CAS No.: 74137-00-1
• Molecular Formula: C27H34 O2 Se
• Molecular Weight: 469.52
• Mol file: 74137-00-1.mol

Synonyms:17a-(Phenylseleno)progesterone

Chemical Property of 17-(phenylseleno)progesterone

Chemical Property:

• Boiling Point: 570.9±50.0 °C(Predicted)
• PSA: 34.14000
• LogP: 5.29570

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 17-(phenylseleno)progesterone

There total 3 articles about 17-(phenylseleno)progesterone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

17α-(phenylseleno)pregnenolone (74157-33-8) → 17alpha-(Phenylseleno)progesterone (74137-00-1)

Guidance literature:

With aluminum tri-tert-butoxide; In cyclohexanone; toluene; for 0.166667h; Heating;

DOI:10.1021/jm00181a004

Reference yield:

Phenylselenyl chloride (5707-04-0) → 17alpha-(Phenylseleno)progesterone (74137-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) MeLi / 1.) THF, 0 deg C, 20 min, 2.) THF, -78 deg C

2: 74 percent / aluminum tert-butoxide / toluene; cyclohexanone / 0.17 h / Heating

With methyllithium; aluminum tri-tert-butoxide; In cyclohexanone; toluene;

DOI:10.1021/jm00181a004

Reference yield:

Acetic acid (8R,9S,10R,13S,14S)-17-[1-acetoxy-eth-(E)-ylidene]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester (115508-80-0) → 17alpha-(Phenylseleno)progesterone (74137-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) MeLi / 1.) THF, 0 deg C, 20 min, 2.) THF, -78 deg C

2: 74 percent / aluminum tert-butoxide / toluene; cyclohexanone / 0.17 h / Heating

With methyllithium; aluminum tri-tert-butoxide; In cyclohexanone; toluene;

DOI:10.1021/jm00181a004

upstream raw materials:

17α-(phenylseleno)pregnenolone

Phenylselenyl chloride

Acetic acid (8R,9S,10R,13S,14S)-17-[1-acetoxy-eth-(E)-ylidene]-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester

Refernces