2-(4-METHYL-PIPERAZINE-1-CARBONYL)-CYCLOHEXANECARBOXYLIC ACID

Base Information

• Chemical Name: 2-(4-METHYL-PIPERAZINE-1-CARBONYL)-CYCLOHEXANECARBOXYLIC ACID
• CAS No.: 331947-27-4
• Molecular Formula: C₁₃H₂₂N₂O₃
• Molecular Weight: 254.329
• Hs Code.: 2933599090
• Mol file: 331947-27-4.mol

Synonyms:TIMTEC-BB SBB011985;2-(4-METHYL-PIPERAZINE-1-CARBONYL)-CYCLOHEXANECARBOXYLIC ACID

Chemical Property of 2-(4-METHYL-PIPERAZINE-1-CARBONYL)-CYCLOHEXANECARBOXYLIC ACID

Chemical Property:

• Vapor Pressure: 2.73E-09mmHg at 25°C
• Boiling Point: 448.4°Cat760mmHg
• Flash Point: 225°C
• PSA: 60.85000
• Density: 1.185g/cm³
• LogP: 0.52720

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Methyl-piperazine-1-carbonyl)-cyclohexanecarboxylic acid ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-METHYL-PIPERAZINE-1-CARBONYL)-CYCLOHEXANECARBOXYLIC ACID

There total 3 articles about 2-(4-METHYL-PIPERAZINE-1-CARBONYL)-CYCLOHEXANECARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-methyl-piperazine (109-01-3) + (-)-trans-1,2-cyclohexanedicarboxylic anhydride → (1R,2R)-2-[(4-methylpiperazin-1-yl)carbonyl]-1-cyclohexanecarboxylic acid (318280-90-9,331947-27-4)

Guidance literature:

In 1,4-dioxane; diethyl ether;

Reference yield:

1-methyl-piperazine (109-01-3) + trans-1,2-cyclohexanedicarboxylic anhydride (85-42-7,13149-00-3,14166-21-3,31982-85-1,71749-03-6,97233-90-4) → (1R,2R)-2-[(4-methylpiperazin-1-yl)carbonyl]-1-cyclohexanecarboxylic acid (318280-90-9,331947-27-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃;

DOI:10.1021/jm3007257

Reference yield:

(1R,2R)-(-)-trans-cyclohexane-1,2-dicarboxylic acid (46022-05-3) → (1R,2R)-2-[(4-methylpiperazin-1-yl)carbonyl]-1-cyclohexanecarboxylic acid (318280-90-9,331947-27-4)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic anhydride / 1 h / 80 °C

2: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 °C

With acetic anhydride; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1021/jm3007257

upstream raw materials:

1-methyl-piperazine

trans-1,2-cyclohexanedicarboxylic anhydride

(1R,2R)-(-)-trans-cyclohexane-1,2-dicarboxylic acid