46022-05-3 Usage
Description
(1R,2R)-(-)-1,2-CYCLOHEXANEDICARBOXYLIC ACID, also known as (1R,2R)-cyclohexane-1,2-dicarboxylic acid, is a chiral dicarboxylic acid with a two-carbon spacer. It is a key component in the formation of cyclodextrin derivatives, which are widely used in various applications due to their unique properties.
Uses
Used in Cyclodextrin Derivatives:
(1R,2R)-(-)-1,2-CYCLOHEXANEDICARBOXYLIC ACID is used as a chiral dicarboxylic acid guest for the formation of cyclodextrin derivatives. It forms CD-active species when combined with other chiral dicarboxylic acids, such as Boc-L-aspartic acid. These cyclodextrin derivatives exhibit unique properties, such as chiral recognition and complexation abilities, making them valuable in various industries.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, (1R,2R)-(-)-1,2-CYCLOHEXANEDICARBOXYLIC ACID is used as a chiral building block for the synthesis of various pharmaceutical compounds. Its unique chiral properties enable the development of enantiomerically pure drugs, which can have improved efficacy and reduced side effects compared to their racemic counterparts.
Used in Food Industry:
In the food industry, (1R,2R)-(-)-1,2-CYCLOHEXANEDICARBOXYLIC ACID is used as a chiral additive to enhance the flavor and aroma of food products. Its ability to form inclusion complexes with various flavor compounds allows for controlled release and improved stability of these compounds in food products.
Used in Cosmetics Industry:
In the cosmetics industry, (1R,2R)-(-)-1,2-CYCLOHEXANEDICARBOXYLIC ACID is used as a chiral ingredient for the development of skincare and fragrance products. Its complexation properties enable the encapsulation of active ingredients, improving their stability, bioavailability, and efficacy in cosmetic formulations.
Used in Environmental Applications:
(1R,2R)-(-)-1,2-CYCLOHEXANEDICARBOXYLIC ACID is used as a chiral adsorbent for the removal of pollutants from water and air. Its ability to selectively bind and remove specific contaminants makes it a valuable tool in environmental remediation efforts.
Check Digit Verification of cas no
The CAS Registry Mumber 46022-05-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 4,6,0,2 and 2 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 46022-05:
(7*4)+(6*6)+(5*0)+(4*2)+(3*2)+(2*0)+(1*5)=83
83 % 10 = 3
So 46022-05-3 is a valid CAS Registry Number.
46022-05-3Relevant articles and documents
Hartmann et al.
, p. 2333,2335 (1973)
AN IMPROVED PROCESS FOR THE PREPARATION OF LURASIDONE HYDROCHLORIDE
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Page/Page column 19, (2016/05/24)
Disclosed herein is an improved process for the preparation of Lurasidone and its pharmaceutically acceptable salts via novel intermediate and use thereof for the preparation of an antipsychotic agent useful for the treatment of schizophrenia and bipolar disorder. Further, present invention provides a cost effective and eco-friendly process for producing Lurasidone hydrochloride of formula (I) substantially free of residual solvent(s) at industrial scale.
A PROCESS FOR PREPARATION OF TRANS (LR,2R)-CYCLO HEXANE 1, 2-DICARBOXYLIC ACID
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, (2014/07/21)
A commercially viable process for industrial preparation of trans-(l R,2R)-cyclohexane 1,2- dicarboxylic acid represented by compound of Formula-I, wherein the compound has more than 99% HPLC purity. The compound of Formula-I is a key intermediate in preparation of Lurasidone hydrochloride which is a well known antipsychotic agent used for treatment of schizophrenia.