2-(4-Bromobenzyl)-1,4-dimethoxybenzene

Base Information

• Chemical Name: 2-(4-Bromobenzyl)-1,4-dimethoxybenzene
• CAS No.: 81974-88-1
• Molecular Formula: C15H15BrO2
• Molecular Weight: 307.187
• NSC Number: 87371
• DSSTox Substance ID: DTXSID20293139
• Nikkaji Number: J1.384.393G
• Wikidata: Q82031759
• Mol file: 81974-88-1.mol

Synonyms:81974-88-1;2-(4-bromobenzyl)-1,4-dimethoxybenzene;NSC87371;NCIOpen2_009424;DTXSID20293139;NSC-87371;2,5-dimethoxy-1-(4 -bromobenzyl)benzene

Chemical Property of 2-(4-Bromobenzyl)-1,4-dimethoxybenzene

Chemical Property:

• Vapor Pressure: 6.54E-06mmHg at 25°C
• Boiling Point: 389.1°C at 760 mmHg
• Flash Point: 166.6°C
• Density: 1.318g/cm³
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 306.02554
• Heavy Atom Count: 18
• Complexity: 239

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)OC)CC2=CC=C(C=C2)Br

Technology Process of 2-(4-Bromobenzyl)-1,4-dimethoxybenzene

There total 10 articles about 2-(4-Bromobenzyl)-1,4-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-(4-bromobenzyl)benzene-1,4-diol + methyl iodide (74-88-4) → 2,5-dimethoxy-1-(4'-bromobenzyl)benzene (81974-88-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; Inert atmosphere;

DOI:10.1007/s00044-017-2127-z

Reference yield: 90.0%

4'-bromo-2,5-dimethoxybenzhydrol (313234-59-2) → 2,5-dimethoxy-1-(4'-bromobenzyl)benzene (81974-88-1)

Guidance literature:

With triethylsilane; trifluorormethanesulfonic acid; In dichloromethane; at 25 ℃; for 0.75h;

DOI:10.1016/S0040-4020(01)00417-3

Reference yield: 48.0%

1-bromomethyl-4-bromobenzene (589-15-1) + 1,4-dimethoxybezene (150-78-7) → 2,5-dimethoxy-1-(4'-bromobenzyl)benzene (81974-88-1) + 1,3-Bis-(4-bromo-benzyl)-2,5-dimethoxy-benzene + 1,4-Bis-(4-bromo-benzyl)-2,5-dimethoxy-benzene

Guidance literature:

With clayzic (ZnCl₂ impregnated on montmorillonite K₁₀); In dichloromethane; at 20 ℃; for 96h;

DOI:10.2478/s11696-011-0073-7

upstream raw materials:

1-bromomethyl-4-bromobenzene

1,4-dimethoxybezene

4'-bromo-2,5-dimethoxybenzhydrol

(4-bromophenyl)(2,5-dimethoxyphenyl)methanone