2-Methoxy-5,6-dihydro[1,1'-biphenyl]-3(4H)-one

Base Information

Chemical Name:2-Methoxy-5,6-dihydro[1,1'-biphenyl]-3(4H)-one
CAS No.:89114-50-1
Molecular Formula:C13H14O2
Molecular Weight:202.253
Hs Code.:
DSSTox Substance ID:DTXSID10526766
Wikidata:Q82395563

Synonyms:89114-50-1;2-Methoxy-5,6-dihydro[1,1'-biphenyl]-3(4H)-one;DTXSID10526766

Suppliers and Price of 2-Methoxy-5,6-dihydro[1,1'-biphenyl]-3(4H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of 2-Methoxy-5,6-dihydro[1,1'-biphenyl]-3(4H)-one

Chemical Property:

PSA：26.30000
LogP:2.79710
XLogP3:2.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:202.099379685
Heavy Atom Count:15
Complexity:272

Purity/Quality:: 85.0-99.8% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:COC1=C(CCCC1=O)C2=CC=CC=C2

Technology Process of 2-Methoxy-5,6-dihydro[1,1'-biphenyl]-3(4H)-one

There total 3 articles about 2-Methoxy-5,6-dihydro[1,1'-biphenyl]-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 445249-11-6
3-bromo-2-methoxycyclohex-2-en-1-one

: 98-80-6
phenylboronic acid

: 89114-50-1
2-methoxy-3-phenylcyclohex-2-en-1-one

Guidance literature:: With palladium diacetate; sodium carbonate; triphenylphosphine; In tetrahydrofuran; water; at 60 ℃; Inert atmosphere;
DOI:10.1055/s-0036-1591543

Reference yield: 70.0%

: 70871-45-3
2-hydroxy-3-phenyl-2-cyclohexen-1-one

: 89114-50-1
2-methoxy-3-phenylcyclohex-2-en-1-one

Guidance literature:: With potassium carbonate; In acetone; for 6h; Heating;
DOI:10.1021/jo00373a015

Reference yield:

: 10324-65-9
3-bromo-2-hydroxy-cyclohex-2-en-1-one

: 89114-50-1
2-methoxy-3-phenylcyclohex-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: sodium carbonate; palladium diacetate; triphenylphosphine / water; tetrahydrofuran / 60 °C / Inert atmosphere

With palladium diacetate; sodium hydride; sodium carbonate; triphenylphosphine; In tetrahydrofuran; water; N,N-dimethyl-formamide; mineral oil; 2.1: |Suzuki Coupling;
DOI:10.1055/s-0036-1591543