1H-Pyrazole, 3-(4-chlorophenyl)-4,5-dihydro-5-(thienyl)-

Base Information

Chemical Name:1H-Pyrazole, 3-(4-chlorophenyl)-4,5-dihydro-5-(thienyl)-
CAS No.:89145-08-4
Molecular Formula:C13H11ClN2S
Molecular Weight:262.763
Hs Code.:
DSSTox Substance ID:DTXSID90406279

Synonyms:1H-Pyrazole, 3-(4-chlorophenyl)-4,5-dihydro-5-(thienyl)-;89145-08-4;SCHEMBL7200601;DTXSID90406279;AKOS002665905;3-(4-chloro-phenyl)-5-thiophen-2-yl-4,5-dihydro-1h-pyrazole

Suppliers and Price of 1H-Pyrazole, 3-(4-chlorophenyl)-4,5-dihydro-5-(thienyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1H-Pyrazole, 3-(4-chlorophenyl)-4,5-dihydro-5-(thienyl)-

Chemical Property:

XLogP3:3.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:262.0331472
Heavy Atom Count:17
Complexity:300

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(NN=C1C2=CC=C(C=C2)Cl)C3=CC=CS3

Technology Process of 1H-Pyrazole, 3-(4-chlorophenyl)-4,5-dihydro-5-(thienyl)-

There total 5 articles about 1H-Pyrazole, 3-(4-chlorophenyl)-4,5-dihydro-5-(thienyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 6028-91-7
1-(4-chlorophenyl)-3-(thiophen-2-yl)prop-2-en-1-one

: 89145-08-4
3-(4-chlorophenyl)-5-thiophen-2-yl-4,5-dihydro-1H-pyrazole

Guidance literature:: With hydrazine hydrate; for 0.25h; Heating;
DOI:10.1021/je00036a038

Reference yield:

: 98-03-3
thiophene-2-carbaldehyde

: 89145-08-4
3-(4-chlorophenyl)-5-thiophen-2-yl-4,5-dihydro-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol / 0 - 10 °C

2: hydrazine hydrate / ethanol / Reflux

With hydrazine hydrate; potassium hydroxide; In ethanol; 1: |Claisen-Schmidt Condensation;
DOI:10.17179/excli2017-871

Reference yield:

: 98-03-3
thiophene-2-carbaldehyde

: 99-91-2
para-chloroacetophenone

: 89145-08-4
3-(4-chlorophenyl)-5-thiophen-2-yl-4,5-dihydro-1H-pyrazole

Guidance literature:: Multi-step reaction with 2 steps

1: potassium hydroxide / ethanol; water / Microwave irradiation

2: hydrazine hydrate / ethanol / 0.11 h / Microwave irradiation

With hydrazine hydrate; potassium hydroxide; In ethanol; water; 1: |Claisen-Schmidt Condensation;
DOI:10.1007/s00044-015-1489-3