5-(Furan-2-yl)-1,3,4-oxadiazol-2-amine

Base Information

• Chemical Name: 5-(Furan-2-yl)-1,3,4-oxadiazol-2-amine
• CAS No.: 7659-06-5
• Molecular Formula: C6H5 N3 O2
• Molecular Weight: 151.125
• Hs Code.: 2934999090
• European Community (EC) Number: 671-513-0
• DSSTox Substance ID: DTXSID40227390
• Nikkaji Number: J42.559A
• Wikidata: Q83107122
• Mol file: 7659-06-5.mol

Synonyms:7659-06-5;5-(furan-2-yl)-1,3,4-oxadiazol-2-amine;5-Furan-2-yl-1,3,4-oxadiazol-2-ylamine;5-(2-furyl)-1,3,4-oxadiazol-2-amine;BRN 0146257;2-Amino-5-(2-furyl)-1,3,4-oxadiazole;1,3,4-Oxadiazole, 2-amino-5-(2-furyl)-;2-Amino-5-(2-Furanyl)-1,3,4-oxadiazole;SCHEMBL1852694;DTXSID40227390;HMS1748M09;AOD100019;MFCD01710630;STK694378;AKOS000117892;SB61346;LS-99072;TS-00062;CS-0032812;FT-0636548;EN300-08601;4-27-00-08950 (Beilstein Handbook Reference);5-furan-2-yl-1,3,4-oxadiazol-2-ylamine, AldrichCPR;Z56943702;F2146-0060

Chemical Property of 5-(Furan-2-yl)-1,3,4-oxadiazol-2-amine

Chemical Property:

• Vapor Pressure: 0.00036mmHg at 25°C
• Melting Point: 7-8?°C(lit.)
• Boiling Point: 318.5°Cat760mmHg
• PKA: -1.53±0.13(Predicted)
• Flash Point: 146.4°C
• PSA: 78.08000
• Density: 1.385g/cm³
• LogP: 1.49300
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 151.038176411
• Heavy Atom Count: 11
• Complexity: 144

Purity/Quality:

98%min ^*data from raw suppliers

5-Furan-2-yl-1,3,4-oxadiazol-2-ylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=COC(=C1)C2=NN=C(O2)N
• Uses: 5-Furan-2-yl-1,3,4-oxadiazol-2-ylamine, can be used in the synthesis of various chemical compounds having therapeutic activity, such as N-[5-(2-Furanyl)-1,3,4-oxadiazol-2-yl]-2-phenyl-4-quinolinecarboxamide (F863670), a small molecular inhibitor of STAT3, a cancer therapeutic agent against Glioblastoma multiforme tumor cells, and a drug target.

Technology Process of 5-(Furan-2-yl)-1,3,4-oxadiazol-2-amine

There total 8 articles about 5-(Furan-2-yl)-1,3,4-oxadiazol-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

furfural (98-01-1) + semicarbazide hydrochloride (563-41-7) → 5-furan-2-yl-[1,3,4]oxadiazol-2-ylamine (7659-06-5)

Guidance literature:

furfural; semicarbazide hydrochloride; With sodium acetate; In methanol; water;

With iodine; potassium carbonate; In 1,4-dioxane; at 80 ℃;

DOI:10.1021/acs.orglett.1c02267

Reference yield: 84.0%

2-(furan-2-ylmethylene)hydrazine-1-carboxamide → 5-furan-2-yl-[1,3,4]oxadiazol-2-ylamine (7659-06-5)

Guidance literature:

With iodine; potassium carbonate; In 1,4-dioxane; at 100 ℃;

DOI:10.2174/1573406417666210803170637

Reference yield: 77.0%

1-(2-furoyl)-3-thiosemicarbazide (35771-64-3) → 5-furan-2-yl-[1,3,4]oxadiazol-2-ylamine (7659-06-5)

Guidance literature:

With Oxone; iodine; sodium hydroxide; In water; isopropyl alcohol; at 0 - 20 ℃; for 0.5h;

DOI:10.3184/174751912X13551638283701

upstream raw materials:

2-furoic acid hydrazide

bromocyane

1-(2-furoyl)-3-thiosemicarbazide

2-furanoic acid

Downstream raw materials:

1-(4-chloro-phenyl)-3-(5-furan-2-yl-[1,3,4]oxadiazol-2-yl)-urea

1-(3,4-dichloro-phenyl)-3-(5-furan-2-yl-[1,3,4]oxadiazol-2-yl)-urea

STX-0119

N-[5-(2-furyl)-1,3,4-oxadiazol-2-yl]-4-iodobenzenecarboxamide