2,4-Dihydroxy-3-phenylquinoline

Base Information

• Chemical Name: 2,4-Dihydroxy-3-phenylquinoline
• CAS No.: 14933-29-0
• Molecular Formula: C15H11 N O2
• Molecular Weight: 237.258
• Mol file: 14933-29-0.mol

Synonyms:Carbostyril,4-hydroxy-3-phenyl- (8CI); NSC 16582

Chemical Property of 2,4-Dihydroxy-3-phenylquinoline

Chemical Property:

• Vapor Pressure: 1.62E-07mmHg at 25°C
• Melting Point: 318 °C
• Boiling Point: 411.8°Cat760mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 202.8°C
• PSA: 53.09000
• Density: 1.323g/cm³
• LogP: 2.90070

Purity/Quality:

97% ^*data from raw suppliers

2,4-DIHYDROXY-3-PHENYLQUINOLINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-Dihydroxy-3-phenylquinoline

There total 37 articles about 2,4-Dihydroxy-3-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

carbon dioxide (124-38-9,18923-20-1) + 2-phenylethynylaniline (13141-38-3) → 4-hydroxy-3-phenyl-2(1H)-quinolone (14933-29-0)

Guidance literature:

With silver nitrate; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; at 60 ℃; for 24h; under 750.075 Torr; Reagent/catalyst; Solvent; Pressure; Time; Catalytic behavior; Schlenk technique;

DOI:10.1021/ol401571r

Reference yield: 93.0%

di(2,4,6-trichlorophenyl)-2-phenylmalonate (15781-73-4) + aniline (62-53-3) → 4-hydroxy-3-phenyl-2(1H)-quinolone (14933-29-0) + 2,4,6-Trichlorophenol (88-06-2,67471-29-8)

Guidance literature:

at 250 ℃; for 0.25h; Further Variations:; Reaction partners; Product distribution; microwave irradiation;

DOI:10.1016/j.tetlet.2006.01.148

Reference yield: 88.0%

aniline (62-53-3) + diethyl 2-phenylmalonate (83-13-6) → 4-hydroxy-3-phenyl-2(1H)-quinolone (14933-29-0) + N1,N3,2-triphenylmalonamide (10256-14-1)

Guidance literature:

at 220 - 270 ℃;

DOI:10.1016/j.tet.2013.10.092

upstream raw materials:

N-phenylacetylanthranilic acid

N¹,N³,2-triphenylmalonamide

N-phenylacetylanthranilic acid ethyl ester

3,N²,N⁴-triphenyl-quinoline-2,4-diyldiamine

Downstream raw materials:

2,4-dichloro-3-phenylquinoline

3-phenylquinoline

4-amino-3-phenylquinoline-2<1H>-one

6-Phenyl-dibenzo<1,6>naphthyridin-11(12H)-on