Phosphonium, [(2-hydroxy-5-methoxyphenyl)methyl]triphenyl-, bromide

Base Information

• Chemical Name: Phosphonium, [(2-hydroxy-5-methoxyphenyl)methyl]triphenyl-, bromide
• CAS No.: 89266-23-9
• Molecular Formula: C26H24O2P.Br
• Molecular Weight: 479.353
• DSSTox Substance ID: DTXSID30468836

Synonyms:(2-hydroxy-5-methoxybenzyl)(triphenyl)phosphonium bromide;Phosphonium, [(2-hydroxy-5-methoxyphenyl)methyl]triphenyl-, bromide;89266-23-9;SCHEMBL4288442;DTXSID30468836;UTPOQJSGZSVNCQ-UHFFFAOYSA-N;A1-21008;[(2-hydroxy-5-methoxy-phenyl)methyl]-triphenyl-phosphonium bromide

Chemical Property of Phosphonium, [(2-hydroxy-5-methoxyphenyl)methyl]triphenyl-, bromide

Chemical Property:

• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 478.06973
• Heavy Atom Count: 30
• Complexity: 432

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)O)C[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4.[Br-]

Technology Process of Phosphonium, [(2-hydroxy-5-methoxyphenyl)methyl]triphenyl-, bromide

There total 4 articles about Phosphonium, [(2-hydroxy-5-methoxyphenyl)methyl]triphenyl-, bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

triphenylphosphine hydrobromide (6399-81-1) + (2-((tert-butyldimethylsilyl)oxy)-5-methoxyphenyl)methanol (736985-95-8) → (2-hydroxy-5-methoxybenzyl)triphenylphosphonium bromide (89266-23-9)

Guidance literature:

triphenylphosphine hydrobromide; (2-((tert-butyldimethylsilyl)oxy)-5-methoxyphenyl)methanol; In acetonitrile; for 2h; Reflux; Inert atmosphere;

With pyridine hydrogenfluoride; In tetrahydrofuran; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jm100531u

Reference yield: 73.0%

2-hydroxy-5-methoxybenzaldehyde (672-13-9) + triphenylphosphine hydrobromide (6399-81-1) → (2-hydroxy-5-methoxybenzyl)triphenylphosphonium bromide (89266-23-9)

Guidance literature:

In acetonitrile; for 2h;

Reference yield:

2-hydroxy-5-methoxybenzaldehyde (672-13-9) → (2-hydroxy-5-methoxybenzyl)triphenylphosphonium bromide (89266-23-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 99.7 percent / NaBH₄ / ethanol / 1 h / 20 °C

2: 84.1 percent / acetonitrile / 1 h / Heating

With sodium tetrahydroborate; In ethanol; acetonitrile;

DOI:10.1021/jm051176k

upstream raw materials:

2-hydroxy-5-methoxybenzaldehyde

triphenylphosphine hydrobromide

(2-((tert-butyldimethylsilyl)oxy)-5-methoxyphenyl)methanol

Downstream raw materials:

2-(2-bromobenzoyloxy)-5-methoxybenzyltriphenylphosphonium bromide

6-methoxy-2-(4-methoxyphenyl)benzofuran

C₂₂H₃₂O₃

[4-(5-methoxy-benzofuran-2-yl)-phenyl]-methyl-amine

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