Ethyl 2-(2-benzamidoethyl)-1,3-thiazole-4-carboxylate

Base Information

Chemical Name:Ethyl 2-(2-benzamidoethyl)-1,3-thiazole-4-carboxylate
CAS No.:30761-31-0
Molecular Formula:C15H16 N2 O3 S
Molecular Weight:304.3641
Hs Code.:
NSC Number:142047
DSSTox Substance ID:DTXSID70301253
Wikidata:Q82044960
ChEMBL ID:CHEMBL2142088
Mol file:30761-31-0.mol

Synonyms:MLS002920537;30761-31-0;NSC142047;CHEMBL2142088;DTXSID70301253;NSC-142047;SMR001798126

Suppliers and Price of Ethyl 2-(2-benzamidoethyl)-1,3-thiazole-4-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of Ethyl 2-(2-benzamidoethyl)-1,3-thiazole-4-carboxylate

Chemical Property:

Vapor Pressure:8.94E-11mmHg at 25°C
Boiling Point:516.5°Cat760mmHg
Flash Point:266.2°C
Density:1.246g/cm³
XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:304.08816355
Heavy Atom Count:21
Complexity:359

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=CSC(=N1)CCNC(=O)C2=CC=CC=C2

Technology Process of Ethyl 2-(2-benzamidoethyl)-1,3-thiazole-4-carboxylate

There total 1 articles about Ethyl 2-(2-benzamidoethyl)-1,3-thiazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 70-23-5
ethyl Bromopyruvate

: 30761-30-9
β-benzamidothiopropionamide

: 30761-31-0
ethyl 2-<(N-benzoylamino)ethyl>thiazole-4-carboxylate

Guidance literature:

Reference yield:

: 30761-31-0
ethyl 2-<(N-benzoylamino)ethyl>thiazole-4-carboxylate

: 142721-50-4
2-{2-[(2S,3R)-3-Hydroxy-2-(2-nitro-phenylsulfanylamino)-butyrylamino]-ethyl}-thiazole-4-carboxylic acid [(R)-2-methylsulfanyl-1-(3-methylsulfanyl-propylcarbamoyl)-ethyl]-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 99 percent / 6 M aq. HCl / 24 h / Heating

2: 72 percent / triethylamine / H₂O; dimethylformamide / 24 h / Ambient temperature

3: 85 percent / 1-hydroxybenzotriazole (HOBt), N,N'-dicyclohexylcarbodiimide (DCC) / acetonitrile / 48 h / Ambient temperature

4: 82 percent / 4.5 M hydrogen chloride in dioxane / 1.) 0 deg C, 3 min, 2.) 25 deg C, 20 min

5: 82 percent / 4-(dimethylamino)pyridine / CH₂Cl₂ / 27 h / 25 °C

With hydrogenchloride; dmap; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/ja00042a002