E-7820

Base Information

Chemical Name:E-7820
CAS No.:289483-69-8
Molecular Formula:C₁₇H₁₂N₄O₂S
Molecular Weight:336.374
Hs Code.:
Mol file:289483-69-8.mol

Synonyms:3-Cyano-N-(3-cyano-4-methyl-1H-indole-7-yl)benzensulfonamide;E 7820

Suppliers and Price of E-7820

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Tocris
E7820 ≥98%(HPLC)
10
$ 207.00

DC Chemicals
E7820 >98%
1 g
$ 1900.00

DC Chemicals
E7820 >98%
100 mg
$ 580.00

ChemScene
E7820 99.36%
25mg
$ 315.00

ChemScene
E7820 99.36%
50mg
$ 450.00

ChemScene
E7820 99.36%
5mg
$ 88.00

ChemScene
E7820 99.36%
10mg
$ 140.00

Cayman Chemical
E7820 ≥98%
5mg
$ 29.00

Cayman Chemical
E7820 ≥98%
10mg
$ 55.00

Cayman Chemical
E7820 ≥98%
50mg
$ 232.00

Total 14 raw suppliers

Chemical Property of E-7820

Chemical Property:

Vapor Pressure:1.34E-15mmHg at 25°C
Boiling Point:626.2°Cat760mmHg
PKA:8.17±0.30(Predicted)
Flash Point:332.5°C
PSA：117.92000
Density:1.48g/cm³
LogP:4.17426

Purity/Quality:

99%, ^*data from raw suppliers

E7820 ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Description E7820 is a sulfonamide derivative and an angiogenesis inhibitor that inhibits bFGF- and VEGF-stimulated human umbilical vein endothelial cell (HUVEC) proliferation (IC50s = 0.1 and 0.081 μg/ml, respectively). It inhibits bFGF- and VEGF-stimulated tube formation of HUVECs in a concentration-dependent manner (IC50s = 0.2 and 0.24 μg/ml, respectively). E7820 selectively decreases the surface expression and mRNA levels of integrin α2 over CD31 and VE-cadherin in HUVECs. In vivo, E7820 (200 and 400 mg/kg) reduces tumor growth and inhibits angiogenesis in a WiDr colorectal cancer mouse xenograft model. It also reduces tumor weight in a panel of seven human colon, breast, pancreas, and kidney cancer mouse xenograft models, completely inhibits tumor growth in KP-1 pancreatic and LoVo colon cancer mouse xenograft models, and inhibits tumor growth in KP-1 and COLO 320DM mouse orthotopic transplantation models.

Technology Process of E-7820

There total 3 articles about E-7820 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 289483-87-0
7-Amino-3-cyano-4-methyl-1H-indole

: 56542-67-7
3-cyanobenzene sulfonyl chloride

: 289483-69-8
N-(3-cyano-4-methyl-1H-indole-7-yl)-3-cyanobenzenesulfonamide

Guidance literature:: 7-Amino-3-cyano-4-methyl-1H-indole; 3-cyanobenzene sulfonyl chloride; With pyridine; In acetic acid methyl ester; water; for 2h;

With hydrogenchloride; In ethanol; acetic acid methyl ester; water;

With pyrographite; In ethanol; acetic acid methyl ester; at 50 ℃; for 0.5h; Product distribution / selectivity;