Phosphine oxide, diphenyl(tetrahydro-2H-pyran-2-yl)-

Base Information

• Chemical Name: Phosphine oxide, diphenyl(tetrahydro-2H-pyran-2-yl)-
• CAS No.: 89455-82-3
• Molecular Formula: C17H19O2P
• Molecular Weight: 286.31
• DSSTox Substance ID: DTXSID00464860
• Mol file: 89455-82-3.mol

Synonyms:Phosphine oxide, diphenyl(tetrahydro-2H-pyran-2-yl)-;89455-82-3;DTXSID00464860;2-diphenyl-phosphoryl-tetrahydro-pyran;diphenyl(tetrahydro-2H-pyran-2-yl)phosphine oxide

Chemical Property of Phosphine oxide, diphenyl(tetrahydro-2H-pyran-2-yl)-

Chemical Property:

• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 286.11226684
• Heavy Atom Count: 20
• Complexity: 321

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCOC(C1)P(=O)(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of Phosphine oxide, diphenyl(tetrahydro-2H-pyran-2-yl)-

There total 9 articles about Phosphine oxide, diphenyl(tetrahydro-2H-pyran-2-yl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

tetrahydro-2H-pyran-2-yl triphenylphosphonium chloride (56061-89-3) → tetrahydro-2H-pyran-2-yl diphenyl phosphine oxide (89455-82-3)

Guidance literature:

With sodium hydroxide; for 0.5h; Heating;

DOI:10.1016/S0040-4020(01)91403-6

Reference yield: 40.0%

3,4-dihydro-2H-pyran (110-87-2) + diphenylphosphane (829-85-6) → tetrahydro-2H-pyran-2-yl diphenyl phosphine oxide (89455-82-3)

Guidance literature:

3,4-dihydro-2H-pyran; diphenylphosphane; dibromobis(triphenylphosphine)nickel(II); In benzene; at 100 ℃; for 10h;

With dihydrogen peroxide; In diethyl ether;

DOI:10.1134/S1070428006010039

Reference yield:

3,4-dihydro-2H-pyran (110-87-2) → tetrahydro-2H-pyran-2-yl diphenyl phosphine oxide (89455-82-3)

Guidance literature:

Multi-step reaction with 2 steps

1: Ni(PPh₃)2Br₂ / benzene / 8 h / 100 °C

2: aq. H₂O₂ / diethyl ether

With dihydrogen peroxide; dibromobis(triphenylphosphine)nickel(II); In diethyl ether; benzene;

DOI:10.1055/s-2003-42092

upstream raw materials:

phenylacetaldehyde

tetrahydro-2H-pyran-2-yl triphenylphosphonium chloride

tetrahydro-2H-pyran-2-yl triphenylphosphonium bromide

3,4-dihydro-2H-pyran

Downstream raw materials:

diphenyl-phosphinic acid

2-<4'-(tetrahydro-2H-pyran-2-yl)oxy butan>-5,6-dihydro-4H-pyran

C₁₄H₂₄O₃

5-[Tetrahydro-pyran-(2E)-ylidene]-pentan-2-ol