4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,8-dihydroxy-7-methoxy-

Base Information

• Chemical Name: 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,8-dihydroxy-7-methoxy-
• CAS No.: 89456-43-9
• Molecular Formula: C16H12O7
• Molecular Weight: 316.267
• Mol file: 89456-43-9.mol

Synonyms:

Chemical Property of 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,8-dihydroxy-7-methoxy-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,8-dihydroxy-7-methoxy-

There total 7 articles about 4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-5,8-dihydroxy-7-methoxy- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

2-(3,4-Dihydroxy-phenyl)-8-hydroxy-5,7-dimethoxy-chromen-4-one (89456-39-3) → hypolaetin 7-methyl ether (89456-43-9)

Guidance literature:

With aluminium trichloride; In acetonitrile; at 70 ℃; for 10h;

DOI:10.1246/bcsj.56.3773

Reference yield:

3-benzyloxy-2-hydroxy-4,6-dimethoxyacetophenone (54299-57-9) → hypolaetin 7-methyl ether (89456-43-9)

Guidance literature:

Multi-step reaction with 5 steps

1: pyridine / 2 h / 120 °C

2: KOH, pyridine / 4 h / 60 °C

3: 96 percent / sodium acetate / acetic acid / 4 h / 140 °C

4: 93 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol

5: 80 percent / AlCl₃ / acetonitrile / 10 h / 70 °C

With pyridine; potassium hydroxide; aluminium trichloride; hydrogen; sodium acetate; palladium on activated charcoal; In methanol; acetic acid; ethyl acetate; acetonitrile;

DOI:10.1246/bcsj.56.3773

Reference yield:

2,3-bis(benzyloxy)-4,6-dimethoxyacetophenone (89456-13-3) → hypolaetin 7-methyl ether (89456-43-9)

Guidance literature:

Multi-step reaction with 6 steps

1: conc.HCl / acetic acid / 1.42 h / Ambient temperature

2: pyridine / 2 h / 120 °C

3: KOH, pyridine / 4 h / 60 °C

4: 96 percent / sodium acetate / acetic acid / 4 h / 140 °C

5: 93 percent / H₂ / 10percent Pd/C / ethyl acetate; methanol

6: 80 percent / AlCl₃ / acetonitrile / 10 h / 70 °C

With pyridine; hydrogenchloride; potassium hydroxide; aluminium trichloride; hydrogen; sodium acetate; palladium on activated charcoal; In methanol; acetic acid; ethyl acetate; acetonitrile;

DOI:10.1246/bcsj.56.3773

upstream raw materials:

2-(3,4-Dihydroxy-phenyl)-8-hydroxy-5,7-dimethoxy-chromen-4-one

3-benzyloxy-2-hydroxy-4,6-dimethoxyacetophenone

3,4-dibenzyloxybenzoyl chloride

2,3-bis(benzyloxy)-4,6-dimethoxyacetophenone