3-(hexadecanoylamino)-2-methoxypropyl 2-(trimethylammonio)ethyl phosphate

Base Information

• Chemical Name: 3-(hexadecanoylamino)-2-methoxypropyl 2-(trimethylammonio)ethyl phosphate
• CAS No.: 112989-00-1
• Molecular Formula: C₂₅H₅₃N₂O₆P
• Molecular Weight: 508.679
• Mol file: 112989-00-1.mol

Synonyms:3,5-Dioxa-9-aza-4-phosphapentacosan-1-aminium,4-hydroxy-7-methoxy-N,N,N-trimethyl-10-oxo-, inner salt, 4-oxide, (?à)-

Chemical Property of 3-(hexadecanoylamino)-2-methoxypropyl 2-(trimethylammonio)ethyl phosphate

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-(hexadecanoylamino)-2-methoxypropyl 2-(trimethylammonio)ethyl phosphate

There total 5 articles about 3-(hexadecanoylamino)-2-methoxypropyl 2-(trimethylammonio)ethyl phosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-3-hexadecanamido-1,2-propanediol (112988-88-2) → rac-2-methoxy-3-octadecanamido-1-propylphosphocholine (112989-00-1)

Guidance literature:

Multi-step reaction with 4 steps

1: pyridine / 10 h / 50 °C

2: 94 percent / NaH / tetrahydrofuran / Ambient temperature

3: 50 percent / boron trifluoride/methanol / CH₂Cl₂ / 4 h / Ambient temperature

4: 1.) NEt₃ / 1.) benzene, RT, 4 h, 2.) CH₃CN, 65 deg C

With methanol; boron trifluoride; sodium hydride; triethylamine; In tetrahydrofuran; pyridine; dichloromethane;

DOI:10.1021/jm00399a029

Reference yield:

(+/-)-3-hexadecanamido-1(triphenylmethoxy)-2-propanol (112988-90-6) → rac-2-methoxy-3-octadecanamido-1-propylphosphocholine (112989-00-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / NaH / tetrahydrofuran / Ambient temperature

2: 50 percent / boron trifluoride/methanol / CH₂Cl₂ / 4 h / Ambient temperature

3: 1.) NEt₃ / 1.) benzene, RT, 4 h, 2.) CH₃CN, 65 deg C

With methanol; boron trifluoride; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00399a029

Reference yield:

(+/-)-3-hexadecanamido-2-methoxy-1-(triphenylmethoxy)propane (112988-92-8) → rac-2-methoxy-3-octadecanamido-1-propylphosphocholine (112989-00-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / boron trifluoride/methanol / CH₂Cl₂ / 4 h / Ambient temperature

2: 1.) NEt₃ / 1.) benzene, RT, 4 h, 2.) CH₃CN, 65 deg C

With methanol; boron trifluoride; triethylamine; In dichloromethane;

DOI:10.1021/jm00399a029

upstream raw materials:

2-Chloro-2-oxo-1,3,2-dioxaphospholane

(+/-)-3-hexadecanamido-2-methoxy-1-propanol

trimethylamine

(+/-)-3-hexadecanamido-1,2-propanediol