Trimethylamine

Base Information

• Chemical Name: Trimethylamine
• CAS No.: 75-50-3
• Deprecated CAS: 4558-12-7
• Molecular Formula: N(CH3)3
• Molecular Weight: 59.1112
• Hs Code.: 2921.11 Oral rat LD50: 90 mg/kg
• European Community (EC) Number: 200-875-0
• ICSC Number: 0206
• NSC Number: 101179
• UN Number: 1083,1297
• UNII: LHH7G8O305
• DSSTox Substance ID: DTXSID2026238
• Nikkaji Number: J1.457E,J1.943.802C
• Wikipedia: Trimethylamine
• Wikidata: Q423953
• Pharos Ligand ID: Q4S7Y3XM5DQ7
• Metabolomics Workbench ID: 37496
• ChEMBL ID: CHEMBL439723
• Mol file: 75-50-3.mol

Synonyms:HBr of trimethylamine;HCl of trimethylamine;HI of trimethylamine;trimethylamine

Chemical Property of Trimethylamine

Chemical Property:

• Appearance/Colour: colourless gas
• Melting Point: 283-284 °C (dec.)(lit.)
• Refractive Index: n20/D 1.357
• Boiling Point: 2.8 °C at 760 mmHg
• PKA: 9.75±0.28(Predicted)
• Flash Point: 38 °F
• PSA: 3.24000
• Density: 0.692 g/cm³
• LogP: 0.17780
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 59.073499291
• Heavy Atom Count: 4
• Complexity: 8
• Transport DOT Label: Flammable Gas

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s): Xi,C,F+,Xn
• Hazard Codes: Xi,C,F+,Xn

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Amines, Aliphatic
• Canonical SMILES: CN(C)C
• Inhalation Risk: A harmful concentration of this gas in the air will be reached very quickly on loss of containment.
• Effects of Short Term Exposure: The substance is severely irritating to the eyes and respiratory tract. Rapid evaporation of the liquid may cause frostbite. Inhalation may cause lung oedema. The effects may be delayed. Medical observation is indicated.

Technology Process of Trimethylamine

There total 845 articles about Trimethylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

triethylsilane (617-86-7) + bis-(dimethylamino)methane (51-80-9) → 1,1,1-triethyl-N,N-dimethylsilylamine (3550-35-4) + trimethylamine (75-50-3)

Guidance literature:

With nickel; at 140 - 150 ℃;

Reference yield:

(2-Phenylethyl)trimethylammonium bromide (6068-85-5) → styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + trimethylamine (75-50-3)

Guidance literature:

With sodium ethanolate; In ethanol; at 40 ℃; Rate constant; kinetic isotope effect;

DOI:10.1021/ja00023a034

Reference yield:

N-trimethyl-B-tris(dimethylamino)borazine (16912-59-7) → boron nitride (10043-11-5) + trimethylamine (75-50-3)

Guidance literature:

at 400°C in high vac.;

DOI:10.1021/ic50005a009

upstream raw materials:

emetine

diazomethane

dimethyl amine

acetamide

Downstream raw materials:

choline

cholin hydroxide

furfuryl-trimethyl-ammonium; bromide

2-cyanopyrimidine

Refernces

• 1、 Keller,Bernhard. "-". . p. 401,417. Retrieved 1925.
• 2、 Bozkurt,Kartal, I.,Karabulut. "γ-irradiated [(CH3)4N]2SiF6 single crystal investigation by electron paramagnetic resonance technique". . p. 308 - 310. Retrieved 2007.
• 3、 Chafetz,Philip. "Trace decomposition of choline". . p. 470 - 471. Retrieved 1982.
• 4、 Haerens, Kurt,Matthijs, Edward,Binnemans, Koen,Van Der Bruggen, Bart. "Electrochemical decomposition of choline chloride based ionic liquid analogues". . p. 1357 - 1365. Retrieved 2009.
• 5、 Bugg, Timothy D. H.,Cameron, Alexander D.,Chen, Yin,Jameson, Eleanor,Quareshy, Mussa,Shanmugam, Muralidharan,Townsend, Eleanor. "Structural basis of carnitine monooxygenase CntA substrate specificity, inhibition, and intersubunit electron transfer". . . Retrieved 2021.
• 6、 Lemmon,Smith. "-". . p. 1395. Retrieved 1963.
• 7、 Fessenden,Neta. "". . p. 2857,2859. Retrieved 1972.
• 8、 Bisai, Milan Kumar,Gour, Kritika,Das, Tamal,Vanka, Kumar,Sen, Sakya S.. "Lithium compound catalyzed deoxygenative hydroboration of primary, secondary and tertiary amides". supporting information. p. 2354 - 2358. Retrieved 2021/03/03.
• 9、 -. "CONSTANT SHEAR CONTINUOUS REACTOR DEVICE". . . Retrieved 2021/02/12.