4-Amino-5-chlorothiophene-2-carboxylic acid;hydrochloride

Base Information

Chemical Name:4-Amino-5-chlorothiophene-2-carboxylic acid;hydrochloride
CAS No.:89499-36-5
Molecular Formula:C₅H₄ClNO₂S*ClH
Molecular Weight:214.072
Hs Code.:
DSSTox Substance ID:DTXSID10527617

Synonyms:89499-36-5;DTXSID10527617;4-Amino-5-chlorothiophene-2-carboxylic acid--hydrogen chloride (1/1)

Suppliers and Price of 4-Amino-5-chlorothiophene-2-carboxylic acid;hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-Amino-5-chlorothiophene-2-carboxylic acid;hydrochloride

Chemical Property:

Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:212.9418050
Heavy Atom Count:11
Complexity:155

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(SC(=C1N)Cl)C(=O)O.Cl

Technology Process of 4-Amino-5-chlorothiophene-2-carboxylic acid;hydrochloride

There total 4 articles about 4-Amino-5-chlorothiophene-2-carboxylic acid;hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 89499-28-5
4-Acetylamino-5-chloro-thiophene-2-carboxylic acid

: 89499-36-5
4-Amino-5-chloro-thiophene-2-carboxylic acid; hydrochloride

Guidance literature:: With hydrogenchloride; Heating;
DOI:10.1007/BF00842830

Reference yield:

: 89166-85-8
5-chloro-4-nitrothiophene-2-carboxylic acid

: 89499-36-5
4-Amino-5-chloro-thiophene-2-carboxylic acid; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 69 percent / Fe / acetic acid / 75 - 80 °C

2: 75 percent / conc. HCl / Heating

With hydrogenchloride; iron; In acetic acid;
DOI:10.1007/BF00842830

Reference yield:

: 57800-76-7
5-chloro-4-nitrothiophene-2-carboxylic acid methyl ester

: 89499-36-5
4-Amino-5-chloro-thiophene-2-carboxylic acid; hydrochloride

Guidance literature:: Multi-step reaction with 2 steps

1: 67 percent / Fe / acetic acid / 75 - 80 °C

2: conc. HCl / Heating

With hydrogenchloride; iron; In acetic acid;
DOI:10.1007/BF00842830