57800-76-7

Basic information

• Product Name: 5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER
• Synonyms: Methyl 5-chloro-4-nitrothiophene-2-carboxylate;5-Chlor-4-nitro-2-thiophencarbonsaeureMethylester;Methyl 5-chloro-4-nitro-2-thiophenecarboxylate;5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER;AKOS 91745;5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER, 95+%;Ethyl 5-chloro-4-nitrothiophene-2-carboxylate
• CAS NO: 57800-76-7
• Molecular Formula: C₆H₄ClNO₄S
• Molecular Weight: 221.62
• Product Categories: API intermediates
• Mol File: 57800-76-7.mol
• Article Data: 5

Chemical Properties

• Melting Point: 83-84 °C
• Boiling Point: 358.168°C at 760 mmHg
• Flash Point: 170.414°C
• Appearance: /
• Density: 1.5g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.583
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER(57800-76-7)
• EPA Substance Registry System: 5-CHLORO-4-NITROTHIOPHENE-2-CARBOXYLIC ACID METHYL ESTER(57800-76-7)

Safety Data

• Hazardous Substances Data: 57800-76-7(Hazardous Substances Data)

Usage

General Description

5-Chloro-4-nitrothiophene-2-carboxylic acid methyl ester is a chemical compound that is used in various pharmaceutical and industrial applications. It is a methyl ester derivative of thieno[2,3-b]thiophene-2-carboxylic acid, which is a heterocyclic compound. This chemical is known for its unique properties and is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and biologically active compounds. It has also been studied for its potential use in the development of new drugs and therapeutic agents. The compound is important in organic synthesis and medicinal chemistry due to its versatility and potential pharmacological activities.

InChI:InChI=1/C7H6ClNO4S/c1-2-13-7(10)5-3-4(9(11)12)6(8)14-5/h3H,2H2,1H3

Upstream product

• 35475-03-7 methyl 5-chloro-2-thiophenecarboxylate 
• 67-56-1 methanol 
• 89166-85-8 5-chloro-4-nitrothiophene-2-carboxylic acid 
• 6310-09-4 2-acetyl-5-chlorothiophene 
• 24065-33-6 5-Chlorothiophene-2-carboxylic acid 

Downstream Products

• 78399-05-0 5-anilino-4-nitro-thiophene-2-carboxylic acid methyl ester 
• 142-04-1 aniline hydrochloride 
• 206050-50-2 5-Benzylsulfanyl-4-nitro-thiophene-2-carboxylic acid methyl ester 
• 159334-03-9 methyl 4-nitro-5-phenoxythiophene-2-carboxylate 
• 1351237-10-9 N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(isopropylamino)thieno[2,3-b]pyrazine-6-carboxamide 
• 1351237-12-1 N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(methylamino)thieno[2,3-b]pyrazine-6-carboxamide 
• 1351237-90-5 N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-3-(ethylamino)thieno[2,3-b]pyrazine-6-carboxamide 
• 1247826-91-0 5-[(2,6-dichlorophenyl)sulfanyl]-N-1-methylpiperidin-4-yl-4-nitrothiophene-2-carboxamide 
• 1247828-46-1 methyl 5-[(2,6-dichlorophenyl)sulfanyl]-4-nitrothiophene-2-carboxylic acid 
• 1247828-43-8 methyl 5-[(2,6-dichlorophenyl)sulfanyl]-4-nitrothiophene-2-carboxylate 
• 1351237-17-6 N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(pyridin-3-yl)thieno[2,3-b]pyrazine-6-carboxamide 
• 1351237-15-4 2-acetyl-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide 
• 1351237-05-2 N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(ethylamino)thieno[2,3-b]pyrazine-6-carboxamide 
• 1351237-03-0 2-chloro-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide 

Relevant articles and documents

Discovery of 3-(thiophen/thiazole-2-ylthio)pyridine derivatives as multitarget anticancer agents

A series of novel 3-(thiophen/thiazole-2-ylthio)pyridine derivatives were designed and synthesized as IGF-1R tyrosine kinase inhibitors. All the target compounds were tested for their IGF-1R kinase inhibitory activities and cytotoxicities against five cancer cell lines (K562, Hep-G2, HCT-116, WSU-DLCL2, and A549). Although all these compounds exhibited moderate to potent cancer cell proliferation inhibitory activities (the most potent compound 43 showed IC50 value of 1.3 ± 0.9 μM against WSU-DLCL2 cell line), IGF-1R inhibition were not observed. In order to identify the exact target of these analogues, selected compounds were further screened for various kinases. The results indicated that this series of compounds may exert their anticancer activities through inhibiting various kinases including FGFR 3, EGFR, JAK, and RON. In addition, cell cycle analysis of compound 43 on Hep-G2 cells showed cell cycle arrest at G1/G0 phase. All the experiments validated the potential of 3-(thiophen/thiazole-2-ylthio)pyridine analogues as multi-target anticancer agents.

Biaryl pyridine deubiquitinating enzyme inhibitor as well as preparation method and application thereof

The invention designs and synthesizes a biaryl pyridine deubiquitinating enzyme inhibitor. The biaryl pyridine deubiquitinating enzyme inhibitor has the structure which is shown as a general formula (I). The biaryl pyridine deubiquitinating enzyme inhibit

5-5-MEMBERED FUSED HETEROCYCLIC COMPOUND AND USE THEREOF AS HCV POLYMERASE INHIBITOR

The present invention relates to a fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and