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Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-4-nitrothiophene-2-carboxylic acid methyl ester is used as a building block for the synthesis of various pharmaceuticals. Its unique properties and versatility make it a valuable component in the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, 5-chloro-4-nitrothiophene-2-carboxylic acid methyl ester is used as a key intermediate in the synthesis of agrochemicals. Its potential to form biologically active compounds makes it a valuable asset in the development of new pesticides and other agrochemical products.
Used in Organic Synthesis:
5-Chloro-4-nitrothiophene-2-carboxylic acid methyl ester is used as a versatile building block in organic synthesis. Its unique structure and reactivity allow for the formation of a wide range of compounds, making it an important tool in the synthesis of various organic molecules.
Used in Medicinal Chemistry:
In medicinal chemistry, 5-chloro-4-nitrothiophene-2-carboxylic acid methyl ester is used for its potential pharmacological activities. Its unique properties and ability to form biologically active compounds make it a promising candidate for the development of new drugs and therapeutic agents.
Used in Research and Development:
5-Chloro-4-nitrothiophene-2-carboxylic acid methyl ester is also used in research and development for its potential applications in various fields. Its unique properties and versatility make it an interesting subject for further studies and exploration of its potential uses in different industries.

InChI:InChI=1/C7H6ClNO4S/c1-2-13-7(10)5-3-4(9(11)12)6(8)14-5/h3H,2H2,1H3

Upstream product

• 24065-33-6 5-Chlorothiophene-2-carboxylic acid 
• 6310-09-4 2-acetyl-5-chlorothiophene 
• 67-56-1 methanol 
• 89166-85-8 5-chloro-4-nitrothiophene-2-carboxylic acid 
• 35475-03-7 methyl 5-chloro-2-thiophenecarboxylate 

Downstream Products

• 78399-05-0 5-anilino-4-nitro-thiophene-2-carboxylic acid methyl ester 
• 142-04-1 aniline hydrochloride 
• 206050-50-2 5-Benzylsulfanyl-4-nitro-thiophene-2-carboxylic acid methyl ester 
• 89499-44-5 4-Amino-5-chloro-thiophene-2-carboxylic acid methyl ester 
• 89499-36-5 4-Amino-5-chloro-thiophene-2-carboxylic acid; hydrochloride 
• 159334-03-9 methyl 4-nitro-5-phenoxythiophene-2-carboxylate 
• 1351237-10-9 N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(isopropylamino)thieno[2,3-b]pyrazine-6-carboxamide 
• 1351237-12-1 N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(methylamino)thieno[2,3-b]pyrazine-6-carboxamide 
• 1351237-90-5 N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-3-(ethylamino)thieno[2,3-b]pyrazine-6-carboxamide 
• 1247826-91-0 5-[(2,6-dichlorophenyl)sulfanyl]-N-1-methylpiperidin-4-yl-4-nitrothiophene-2-carboxamide 
• 1247828-46-1 methyl 5-[(2,6-dichlorophenyl)sulfanyl]-4-nitrothiophene-2-carboxylic acid 
• 1247828-43-8 methyl 5-[(2,6-dichlorophenyl)sulfanyl]-4-nitrothiophene-2-carboxylate 
• 1351237-17-6 N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)-2-(pyridin-3-yl)thieno[2,3-b]pyrazine-6-carboxamide 
• 1351237-15-4 2-acetyl-N-(5-(3-(2-cyanopropan-2-yl)benzamido)-2-methylphenyl)thieno[2,3-b]pyrazine-6-carboxamide 

Relevant academic research and scientific papers

Discovery of 3-(thiophen/thiazole-2-ylthio)pyridine derivatives as multitarget anticancer agents

A series of novel 3-(thiophen/thiazole-2-ylthio)pyridine derivatives were designed and synthesized as IGF-1R tyrosine kinase inhibitors. All the target compounds were tested for their IGF-1R kinase inhibitory activities and cytotoxicities against five cancer cell lines (K562, Hep-G2, HCT-116, WSU-DLCL2, and A549). Although all these compounds exhibited moderate to potent cancer cell proliferation inhibitory activities (the most potent compound 43 showed IC50 value of 1.3 ± 0.9 μM against WSU-DLCL2 cell line), IGF-1R inhibition were not observed. In order to identify the exact target of these analogues, selected compounds were further screened for various kinases. The results indicated that this series of compounds may exert their anticancer activities through inhibiting various kinases including FGFR 3, EGFR, JAK, and RON. In addition, cell cycle analysis of compound 43 on Hep-G2 cells showed cell cycle arrest at G1/G0 phase. All the experiments validated the potential of 3-(thiophen/thiazole-2-ylthio)pyridine analogues as multi-target anticancer agents.

BUMETANIDE DERIVATIVES FOR THE THERAPY OF HYPERHIDROSIS

The present invention relates to bumetanide derivatives of formula (I) as well as pharmaceutical compositions comprising these compounds for use in the treatment or prevention of diseases/disorders involving Na+- K+- 2CI- - cotransporters (NKCCs), and particularly for use in the treatment or prevention of hyperhidrosis.

Biaryl pyridine deubiquitinating enzyme inhibitor as well as preparation method and application thereof

The invention designs and synthesizes a biaryl pyridine deubiquitinating enzyme inhibitor. The biaryl pyridine deubiquitinating enzyme inhibitor has the structure which is shown as a general formula (I). The biaryl pyridine deubiquitinating enzyme inhibit

HETEROCYCLIC DERIVATIVES AND USE THEREOF

A heterocyclic derivative represented by formula (I), or a pharmaceutically acceptable salt or a stereoisomer thereof, which has an inhibitory effect on the activation of STAT3 protein, and is useful for the prevention or treatment of diseases associated with the activation of STAT3 protein.

5-5-MEMBERED FUSED HETEROCYCLIC COMPOUND AND USE THEREOF AS HCV POLYMERASE INHIBITOR

The present invention relates to a fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and