6-(5-{[5-cyano-1,4-dimethyl-2-(3-methylpiperidin-1-yl)-6-oxo-1,6-dihydropyridin-3-yl]methylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)hexanoic acid

Base Information

• Chemical Name: 6-(5-{[5-cyano-1,4-dimethyl-2-(3-methylpiperidin-1-yl)-6-oxo-1,6-dihydropyridin-3-yl]methylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)hexanoic acid
• CAS No.: 7063-30-1
• Molecular Formula: C24H30N4O4S2
• Molecular Weight: 203.284

Synonyms:

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Chemical Property of 6-(5-{[5-cyano-1,4-dimethyl-2-(3-methylpiperidin-1-yl)-6-oxo-1,6-dihydropyridin-3-yl]methylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)hexanoic acid

Chemical Property:

• Vapor Pressure: 1.1E-13mmHg at 25°C
• Boiling Point: 553°Cat760mmHg
• Flash Point: 288.2°C
• Density: 1.37g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(5-{[5-cyano-1,4-dimethyl-2-(3-methylpiperidin-1-yl)-6-oxo-1,6-dihydropyridin-3-yl]methylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)hexanoic acid

There total 11 articles about 6-(5-{[5-cyano-1,4-dimethyl-2-(3-methylpiperidin-1-yl)-6-oxo-1,6-dihydropyridin-3-yl]methylidene}-4-oxo-2-thioxo-1,3-thiazolidin-3-yl)hexanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(methylamino)-2-phenylcyclohexan-1-one hydrochloride (4631-27-0) → (R)-2-(methylamino)-2-phenylcyclohexan-1-one (7063-30-1) + (S)-2-(methylamino)-2-phenylcyclohexan-1-one

Guidance literature:

2-(methylamino)-2-phenylcyclohexan-1-one hydrochloride; With sodium hydroxide; In methanol; at 20 ℃; for 0.5h;

In methanol; hexane; isopropyl alcohol; Resolution of racemate;

Reference yield:

1-Hydroxycyclopentyl-phenylketon-N-methylimin (6740-84-7) → 2-phenyl-2-(methylamino)cyclohexan-1-one (7063-30-1)

Guidance literature:

With N,N,N,N,-tetramethylethylenediamine; nickel dichloride; In butan-1-ol; at 130 ℃; for 72h;

DOI:10.1016/S0957-4166(03)00433-6

Reference yield:

1-Hydroxy-cyclopentyl-(phenyl)-N-methylketimin (6740-84-7) → 2-phenyl-2-(methylamino)cyclohexan-1-one (7063-30-1)

Guidance literature:

In decalin; at 190 ℃; for 4h; Microwave irradiation;

DOI:10.1039/c8nj03107j

upstream raw materials:

1-Hydroxycyclopentyl-phenylketon-N-methylimin

1-Hydroxy-cyclopentyl-(phenyl)-N-methylketimin

2-(methylamino)-2-phenylcyclohexan-1-one hydrochloride

phenyl cyclopentyl ketone

Downstream raw materials:

7-aza-11,12-dioxa-7-methyl-6-phenyltricyclo[ 7,2,1,01,6 ]dodecane

2-(methylamino)-2-phenylcyclohexan-1-one hydrochloride

formaldehyd

2-amino-2-phenylcyclohexan-1-one