ethyl 3-amino-5-methoxy-1H-indole-2-carboxylate

Base Information

Chemical Name:ethyl 3-amino-5-methoxy-1H-indole-2-carboxylate
CAS No.:89607-80-7
Molecular Formula:C12H14N2O3
Molecular Weight:234.255
Hs Code.:
DSSTox Substance ID:DTXSID30355671
Wikidata:Q82134693
Mol file:89607-80-7.mol

Synonyms:ethyl 3-amino-5-methoxy-1H-indole-2-carboxylate;89607-80-7;1217644-25-1;3-Amino-5-methoxy-1H-indole-2-carboxylic acid ethyl ester;1H-Indole-2-carboxylic acid, 3-amino-5-methoxy-, ethyl ester;ChemDiv1_009118;Oprea1_090643;Oprea1_721495;HMS612O10;DTXSID30355671;DEKRXQYFEJCJEZ-UHFFFAOYSA-N;BBL007765;MFCD00435614;STK386383;2-carbethoxy-3-amino-5-methoxyindole;AKOS000264800;AT24095;BS-4416;CS-0070492;EN300-235827;ethyl3-amino-5-methoxy-1H-indole-2-carboxylate;SR-01000478912;SR-01000478912-1;F0037-1475

Suppliers and Price of ethyl 3-amino-5-methoxy-1H-indole-2-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
3-Amino-5-methoxy-1H-indole-2-carboxylic acidethyl ester
500mg
$ 194.00

Chemenu
Ethyl3-amino-5-methoxy-1H-indole-2-carboxylate 95%+
1g
$ 203.00

Total 3 raw suppliers

Chemical Property of ethyl 3-amino-5-methoxy-1H-indole-2-carboxylate

Chemical Property:

PSA：77.34000
LogP:2.51660
XLogP3:2.4
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:234.10044231
Heavy Atom Count:17
Complexity:285

Purity/Quality:

98%min ^*data from raw suppliers

3-Amino-5-methoxy-1H-indole-2-carboxylic acidethyl ester ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:Xi

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C1=C(C2=C(N1)C=CC(=C2)OC)N
Uses Ethyl 3-amino-5-methoxy-1H-indole-2-carboxylate is used as a reactant in the reductive aminations of carbonyl compounds with borohydride and borane reducing agents.

Technology Process of ethyl 3-amino-5-methoxy-1H-indole-2-carboxylate

There total 3 articles about ethyl 3-amino-5-methoxy-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: ethyl 2-[(2-cyano-4-methoxyphenyl)amino]acetate

: 89607-80-7
ethyl 3-amino-5-methoxy-1H-indole-2-carboxylate

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 2h; Cooling with ice; Inert atmosphere;
DOI:10.1016/j.bioorg.2020.103665

Reference yield:

: 23842-82-2
2-amino-5-methoxybenzonitrile

: 89607-80-7
ethyl 3-amino-5-methoxy-1H-indole-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / acetonitrile / 48 h / Reflux; Inert atmosphere

2: potassium tert-butylate / tetrahydrofuran / 2 h / 20 °C / Cooling with ice; Inert atmosphere

With potassium tert-butylate; sodium hydrogencarbonate; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.bioorg.2020.103665