23842-82-2

Usage

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-Amino-5-methoxybenzonitrile is used as a starting material for the production of heterocyclic compounds, which have diverse applications in medicinal and agricultural chemistry. Its unique structure allows for the synthesis of a wide range of biologically active compounds, including anti-inflammatory and antibacterial agents.
Used in Dye and Fluorescent Brightening Agent Industries:
2-Amino-5-methoxybenzonitrile is employed as an intermediate in the preparation of dyes and fluorescent brightening agents for textiles and plastics. Its chemical properties enable the development of colorants and brighteners with specific characteristics, enhancing the performance and aesthetics of various materials.
Used in the Synthesis of Biologically Active Compounds:
2-Amino-5-methoxybenzonitrile is used as a building block in the synthesis of various biologically active compounds. Its presence in the molecular structure of these compounds contributes to their therapeutic or pesticidal properties, making it an essential component in the development of new drugs and agrochemicals.

Upstream product

• 38469-84-0 2-nitro-5-methoxybenzonitrile 
• 104-94-9 4-methoxy-aniline 
• 545-06-2 trichloroacetonitrile 
• 42454-06-8 2-nitro-5-hydroxybenzaldehyde 
• 20357-24-8 5-methoxy-2-nitro-benzaldehyde 
• 39755-95-8 5-methoxyisatine 
• 109103-45-9 5-methoxy-indoline-2,3-dione-3-oxime 
• 109103-45-9 3-(hydroxyimino)-5-methoxyindolin-2-one 
• 1262111-11-4 2-azido-5-methoxybenzonitrile 
• 75-16-1 methylmagnesium bromide 
• 1882-69-5 5-methoxy-2-nitro-benzoic acid 
• 1527-89-5 3-methoxybenzonitrile 
• 191348-14-8 2-iodo-4-methoxylaniline 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 39495-44-8 5-Methoxy-2-nitrosobenzonitril 
• 402842-51-7 5-methoxy-2-(5-oxo-5,6-dihydro-2H-thiopyran-3-ylamino)-benzonitrile 
• 939970-63-5 O-ethyl ester of 2-cyano-4-methoxyphenyl dithiocarbonic acid 
• 51-79-6 urethane 
• 116423-56-4 (2-cyano-4-methoxy-phenyl)-carbamic acid ethyl ester 
• 35364-15-9 2'-amino-5'-hydroxypropiophenone 
• 1262111-11-4 2-azido-5-methoxybenzonitrile 
• 105763-77-7 2,4-dichloro-6-methoxy-quinazoline 
• 1417711-17-1 RuH(CO)(1-(6-amino-3-methoxyphenyl)-2,2-dimethyl-1-propanone(-1H))(PPh₃)₂ 
• 1417711-14-8 1-(6-amino-3-methoxyphenyl)-2,2-dimethyl-1-propanone 
• 1567785-97-0 2-((cyanomethyl)amino)-5-methoxybenzonitrile 
• 32618-84-1 6-Methoxyquinazolin-2,4-dione 
• 1065474-24-9 3-methoxy-6-(methylamino)benzonitrile 
• 1315314-52-3 6-methoxy-2,4-diphenylquinazoline 

Relevant academic research and scientific papers

Pyridyl Radical Cation for C?H Amination of Arenes

Electron-transfer photocatalysis provides access to the elusive and unprecedented N-pyridyl radical cation from selected N-substituted pyridinium reagents. The resulting C(sp2)?H functionalization of (hetero)arenes furnishes versatile intermediates for the development of valuable aminated aryl scaffolds. Mechanistic studies that include the first spectroscopic evidence of a spin-trapped N-pyridyl radical adduct implicate SET-triggered, pseudo-mesolytic cleavage of the N?X pyridinium reagents mediated by visible light.

Metal-free chemoselective reduction of nitroaromatics to anilines via hydrogen transfer strategy

A novel protocol for chemoselective reduction of aromatic nitro compounds to aromatic amines has been established. The metal-free reduction goes through a hydrogen transfer process. Various easily reducible functional groups can be well tolerated under the optimized reaction conditions.

Substituent effects on stoichiometric and catalytic cleavage of carbon-nitrogen bonds in aniline derivatives by ruthenium-phosphine complexes

The reactivity of various o-acylaniline derivatives with ruthenium complexes was examined. The reaction of o-acylanilines with RuH 2(CO)(PPh3)3 (1) or an activated ruthenium species formulated as "Ru(CO)(PPh3)s

HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE

The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.

Synthesis of benzotriazine and aryltriazene derivatives starting from 2-azidobenzonitrile derivatives

3-Substituted 3,4-dihydro-4-imino-1,2,3-benzotriazine derivatives 7 were formed from 2-azidobenzonitriles 4 as starting materials on treatment with Grignard or lithium organic reagents. In some cases these procedures gave aryltriazenes 10 and 11 as products. All compounds were identified by NMR spectroscopy and the structures of three products, namely 7a, 10a and 11i, were corroborated by X-ray crystallography. The reactions of 2-azidobenzonitrile derivatives with Grignard reagents have been investigated. These reactions, depending on the type of Grignard reagent and the substituents on the 2-azidobenzonitrile derivatives, resulted in benzotriazines and triazenes. Copyright

HETEROCYCLIC INHIBITORS OF HISTAMINE RECEPTORS FOR THE TREATMENT OF DISEASE

The present invention relates to compounds and methods which may be useful as inhibitors of H1R and/or H4R for the treatment or prevention of inflammatory, autoimmune, allergic, and ocular diseases.

SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS

Compounds of Formula (I) or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB1receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.

A catalytic antibody against a tocopherol cyclase inhibitor

The cyclic ammonium cation 5 and its guanidinium analogue 4 areinhibitors of tocopherol cyclase. Monoclonal antibodies were raised against protein conjugates of the haptens 1-3 and screened for catalytic reactions with alkene 8, a short chain analogue of

EXLUSIVE ORTHO CYANATION AND ALKYLTHIOCARBONYLATION OF ANILINES AND PHENOLS USING BORON TRICHLORIDE

Use of boron trichloride with or without an aditional Lewis acid makes possible a one-step synthesis of 2-cyano and 2-alkylthiocarbonyl anilines and phenols.