2-(Diphenylphosphoryl)-4-hydroxy-2-methyl-1-phenylbutan-1-one

Base Information

Chemical Name:2-(Diphenylphosphoryl)-4-hydroxy-2-methyl-1-phenylbutan-1-one
CAS No.:89625-15-0
Molecular Formula:C23H23O3P
Molecular Weight:378.408
Hs Code.:
DSSTox Substance ID:DTXSID30526748

Synonyms:89625-15-0;DTXSID30526748;2-(Diphenylphosphoryl)-4-hydroxy-2-methyl-1-phenylbutan-1-one

Suppliers and Price of 2-(Diphenylphosphoryl)-4-hydroxy-2-methyl-1-phenylbutan-1-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(Diphenylphosphoryl)-4-hydroxy-2-methyl-1-phenylbutan-1-one

Chemical Property:

XLogP3:3.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:7
Exact Mass:378.13848159
Heavy Atom Count:27
Complexity:506

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(CCO)(C(=O)C1=CC=CC=C1)P(=O)(C2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 2-(Diphenylphosphoryl)-4-hydroxy-2-methyl-1-phenylbutan-1-one

There total 3 articles about 2-(Diphenylphosphoryl)-4-hydroxy-2-methyl-1-phenylbutan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 89625-13-8
Benzoic acid 3-(diphenyl-phosphinoyl)-butyl ester

: 89625-15-0
2-diphenylphosphinoyl-4-hydroxy-2-methyl-1-phenylbutan-1-one

Guidance literature:: With lithium diisopropyl amide; at -78 ℃;
DOI:10.1016/S0040-4039(00)99882-4

Reference yield:

: 89625-12-7,1160942-82-4
3-diphenylphosphinoylbutan-1-ol

: 89625-15-0
2-diphenylphosphinoyl-4-hydroxy-2-methyl-1-phenylbutan-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / pyridine

2: 82 percent / lithium diisopropylamide / tetrahydrofuran / 0.25 h / -78 °C

With pyridine; lithium diisopropyl amide; In tetrahydrofuran;

Reference yield:

: 1733-57-9
ethydiphenylphosphine oxide

: 89625-15-0
2-diphenylphosphinoyl-4-hydroxy-2-methyl-1-phenylbutan-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 1) n-butyl-lithium / 1) THF, hexane, -20 deg C, 30 min, 2) THF, hexane, -20 deg C, 2 h

2: 85 percent / pyridine

3: 82 percent / lithium diisopropylamide / tetrahydrofuran / 0.25 h / -78 °C

With pyridine; n-butyllithium; lithium diisopropyl amide; In tetrahydrofuran;