3-(Diphenylphosphoryl)butan-1-ol

Base Information

• Chemical Name: 3-(Diphenylphosphoryl)butan-1-ol
• CAS No.: 89625-12-7
• Molecular Formula: C₁₆H₁₉O₂P
• Molecular Weight: 274.299
• DSSTox Substance ID: DTXSID10526746
• Mol file: 89625-12-7.mol

Synonyms:3-(Diphenylphosphoryl)butan-1-ol;89625-12-7;DTXSID10526746

Chemical Property of 3-(Diphenylphosphoryl)butan-1-ol

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 274.11226684
• Heavy Atom Count: 19
• Complexity: 282

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(CCO)P(=O)(C1=CC=CC=C1)C2=CC=CC=C2

Technology Process of 3-(Diphenylphosphoryl)butan-1-ol

There total 1 articles about 3-(Diphenylphosphoryl)butan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

oxirane (75-21-8,99932-75-9) + ethydiphenylphosphine oxide (1733-57-9) → 3-diphenylphosphinoylbutan-1-ol (89625-12-7,1160942-82-4)

Guidance literature:

With n-butyllithium; Multistep reaction;

DOI:10.1016/S0040-4039(00)99882-4

Reference yield: 85.0%

3-diphenylphosphinoylbutan-1-ol (89625-12-7,1160942-82-4) + benzoyl chloride (98-88-4) → Benzoic acid 3-(diphenyl-phosphinoyl)-butyl ester (89625-13-8)

Guidance literature:

With pyridine;

DOI:10.1016/S0040-4039(00)99882-4

Reference yield:

3-diphenylphosphinoylbutan-1-ol (89625-12-7,1160942-82-4) → threo-2-diphenylphosphinoyl-2-methyl-1-phenylbutane-1,4-diol (89625-18-3,89625-20-7,146964-18-3,146964-19-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / pyridine

2: 82 percent / lithium diisopropylamide / tetrahydrofuran / 0.25 h / -78 °C

3: NaBH₄ / methanol / 2 h

With pyridine; sodium tetrahydroborate; lithium diisopropyl amide; In tetrahydrofuran; methanol;

upstream raw materials:

oxirane

ethydiphenylphosphine oxide

Downstream raw materials:

erythro-2-diphenylphosphinoyl-2-methyl-1-phenylbutane-1,4-diol

2-Diphenylphosphinoyl-2-methyl-1-phenylbutane-1,4-diol

Benzoic acid 3-(diphenyl-phosphinoyl)-butyl ester

threo-2-diphenylphosphinoyl-2-methyl-1-phenylbutane-1,4-diol