(E)-1-(2-Benzylpyrrolidin-1-yl)-N-tert-butylmethanimine

Base Information

Chemical Name:(E)-1-(2-Benzylpyrrolidin-1-yl)-N-tert-butylmethanimine
CAS No.:89656-30-4
Molecular Formula:C16H24N2
Molecular Weight:244.38
Hs Code.:
DSSTox Substance ID:DTXSID90534627

Synonyms:89656-30-4;(E)-1-(2-Benzylpyrrolidin-1-yl)-N-tert-butylmethanimine;DTXSID90534627

Suppliers and Price of (E)-1-(2-Benzylpyrrolidin-1-yl)-N-tert-butylmethanimine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-1-(2-Benzylpyrrolidin-1-yl)-N-tert-butylmethanimine

Chemical Property:

XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:4
Exact Mass:244.193948774
Heavy Atom Count:18
Complexity:271

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)N=CN1CCCC1CC2=CC=CC=C2

Technology Process of (E)-1-(2-Benzylpyrrolidin-1-yl)-N-tert-butylmethanimine

There total 6 articles about (E)-1-(2-Benzylpyrrolidin-1-yl)-N-tert-butylmethanimine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 119044-70-1
(E)-N′-tert-butyl-N,N-dimethylformimidamide

: 89656-30-4
[1-(2-Benzyl-pyrrolidin-1-yl)-meth-(E)-ylidene]-tert-butyl-amine

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / (NH₄)2SO₄ / toluene / Heating

2: 1.) t-BuLi; 2.) hexamethylphosphoramide / 1.) THF, -20 deg C, 1 h; 2.) THF, -78 -> 0 deg C, 3 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; ammonium sulfate; tert.-butyl lithium; In toluene;
DOI:10.1021/ja00323a035

Reference yield:

: 119072-55-8,7188-38-7
tert-butylisonitrile

: 89656-30-4
[1-(2-Benzyl-pyrrolidin-1-yl)-meth-(E)-ylidene]-tert-butyl-amine

Guidance literature:: Multi-step reaction with 4 steps

1: 85 percent / Cu₂O / toluene / 24 h / Heating

2: 85 percent / Red-Al / tetrahydrofuran / 0 - 25 °C

3: 80 percent / NaH / tetrahydrofuran / 0 °C

4: diethyl ether / 12 h / Ambient temperature

With sodium hydride; sodium bis(2-methoxyethoxy)aluminium dihydride; copper(I) oxide; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1016/S0040-4039(00)97716-5

Reference yield:

: 100-39-0
benzyl bromide

: 85152-51-8
1-<(tert-butyl)formimidoyl>pyrrolidine

: 89656-30-4
[1-(2-Benzyl-pyrrolidin-1-yl)-meth-(E)-ylidene]-tert-butyl-amine

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; tert.-butyl lithium; Yield given. Multistep reaction; 1.) THF, -20 deg C, 1 h; 2.) THF, -78 -> 0 deg C, 3 h;
DOI:10.1021/ja00323a035