(7-Methyl-1H-indol-2-yl)(phenyl)methanone

Base Information

• Chemical Name: (7-Methyl-1H-indol-2-yl)(phenyl)methanone
• CAS No.: 89671-77-2
• Molecular Formula: C16H13NO
• Molecular Weight: 235.285
• DSSTox Substance ID: DTXSID10525673
• Wikidata: Q82393440

Synonyms:89671-77-2;(7-Methyl-1H-indol-2-yl)(phenyl)methanone;DTXSID10525673

Chemical Property of (7-Methyl-1H-indol-2-yl)(phenyl)methanone

Chemical Property:

• XLogP3: 4.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 235.099714038
• Heavy Atom Count: 18
• Complexity: 308

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C2C(=CC=C1)C=C(N2)C(=O)C3=CC=CC=C3

Technology Process of (7-Methyl-1H-indol-2-yl)(phenyl)methanone

There total 7 articles about (7-Methyl-1H-indol-2-yl)(phenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(2-(chloromethyl)-6-methylphenyl)-4-methylbenzenesulfonamide (895578-41-3) + (benzoylmethylene)dimethylsulfurane (5633-34-1) → (7-methyl-1H-indol-2-yl)(phenyl)methanone (89671-77-2)

Guidance literature:

(benzoylmethylene)dimethylsulfurane; With caesium carbonate; In 5,5-dimethyl-1,3-cyclohexadiene; at 20 ℃; for 0.5h;

N-(2-chloromethyl-6-methyl-phenyl)-4-methyl-benzenesulfonamide; In 5,5-dimethyl-1,3-cyclohexadiene; at 20 - 60 ℃;

DOI:10.1002/anie.201203657

Reference yield: 83.0%

N-(2-methyl-6-(3-oxo-3-phenylpropyl)phenyl)-4-methylbenzenesulfonamide (1435944-05-0) → (7-methyl-1H-indol-2-yl)(phenyl)methanone (89671-77-2)

Guidance literature:

With iodine; potassium carbonate; In methanol; at 60 ℃; for 3h;

DOI:10.1039/c3cc40797g

Reference yield: 82.0%

(7-methyl-1-(pyrimidin-2-yl)-1H-indol-2-yl)(phenyl)methanone (1427669-92-8) → (7-methyl-1H-indol-2-yl)(phenyl)methanone (89671-77-2)

Guidance literature:

With sodium ethanolate; In dimethyl sulfoxide; at 100 ℃; for 24h; Inert atmosphere;

DOI:10.1039/c3cc40709h

upstream raw materials:

7-Methyl-1-(2-oxo-2-phenyl-ethyl)-1H-indole-2,3-dione

N-(2-(chloromethyl)-6-methylphenyl)-4-methylbenzenesulfonamide

(benzoylmethylene)dimethylsulfurane

(7-methyl-1-(pyrimidin-2-yl)-1H-indol-2-yl)(phenyl)methanone

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