N-(2-(chloromethyl)-6-methylphenyl)-4-methylbenzenesulfonamide

Base Information

• Chemical Name: N-(2-(chloromethyl)-6-methylphenyl)-4-methylbenzenesulfonamide
• CAS No.: 895578-41-3
• Molecular Formula: C₁₅H₁₆ClNO₂S
• Molecular Weight: 309.817
• Mol file: 895578-41-3.mol

Synonyms:N-(2-(chloromethyl)-6-methylphenyl)-4-methylbenzenesulfonamide

Chemical Property of N-(2-(chloromethyl)-6-methylphenyl)-4-methylbenzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of N-(2-(chloromethyl)-6-methylphenyl)-4-methylbenzenesulfonamide

There total 5 articles about N-(2-(chloromethyl)-6-methylphenyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(2-(hydroxymethyl)-6-methylphenyl)-4-methylbenzenesulfonamide (895578-40-2) → N-(2-(chloromethyl)-6-methylphenyl)-4-methylbenzenesulfonamide (895578-41-3)

Guidance literature:

DOI:10.1021/ol060327q

Reference yield:

2-amino-3-methylbenzyl alcohol (57772-50-6) → N-(2-(chloromethyl)-6-methylphenyl)-4-methylbenzenesulfonamide (895578-41-3)

Guidance literature:

DOI:10.1021/ol060327q

Reference yield:

3-methylantranilic acid (4389-45-1) → N-(2-(chloromethyl)-6-methylphenyl)-4-methylbenzenesulfonamide (895578-41-3)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3.5 h / 20 °C

2: pyridine / chloroform

3: thionyl chloride / chloroform

With pyridine; lithium aluminium tetrahydride; thionyl chloride; In tetrahydrofuran; chloroform;

DOI:10.1016/j.tetlet.2017.07.090

upstream raw materials:

N-(2-(hydroxymethyl)-6-methylphenyl)-4-methylbenzenesulfonamide

2-amino-3-methylbenzyl alcohol

p-toluenesulfonyl chloride

3-methylantranilic acid

Downstream raw materials:

2-(bromomethyl)-8-methyl-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline

N-(2-(but-3-en-1-yl)-6-methylphenyl)-4-methylbenzenesulfonamide