5-Acetyl-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-2-one

Base Information

Chemical Name:5-Acetyl-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-2-one
CAS No.:89680-94-4
Molecular Formula:C17H23NO4
Molecular Weight:305.374
Hs Code.:
DSSTox Substance ID:DTXSID10495206

Synonyms:89680-94-4;DTXSID10495206;5-Acetyl-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-2-one

Suppliers and Price of 5-Acetyl-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-Acetyl-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-2-one

Chemical Property:

XLogP3:1.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:305.16270821
Heavy Atom Count:22
Complexity:398

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)C1CCC(=O)N(C1)CCC2=CC(=C(C=C2)OC)OC

Technology Process of 5-Acetyl-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-2-one

There total 1 articles about 5-Acetyl-1-[2-(3,4-dimethoxyphenyl)ethyl]piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89680-94-4
5-acetyl-1-(3,4-dimethoxy-phenethyl)-piperidin-2-one

Guidance literature:: entspr. Lactamalkohol (8c), H2, Pd/C;

Reference yield: 82.0%

: 89680-94-4
5-acetyl-1-(3,4-dimethoxy-phenethyl)-piperidin-2-one

: 78867-70-6
1-(3,4-dimethoxyphenethyl)-5-ethyl-2-piperidinone

Guidance literature:: With potassium hydroxide; hydrazine hydrate; In water; ethylene glycol; 120 degC, 1 h then 190-195 degC, 3 h;
DOI:10.1248/cpb.33.5316

Reference yield:

: 89680-94-4
5-acetyl-1-(3,4-dimethoxy-phenethyl)-piperidin-2-one

: 78867-74-0,89681-00-5,107343-23-7
1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidinemalonic acid diethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / hydrazine hydrate, KOH / H₂O; ethane-1,2-diol / 120 degC, 1 h then 190-195 degC, 3 h

2: 91 percent / diisopropylamine, n-butyllithium, hexamethylphosphoramide / tetrahydrofuran; hexane / 2 h / -78 °C

3: sodium metaperiodate / methanol; H₂O / 18 h / Ambient temperature

4: CaCO₃ / toluene / 1 h / Heating

5: NaOEt / ethanol / 70 degC, 2 h, reflux, 6 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sodium periodate; n-butyllithium; sodium ethanolate; hydrazine hydrate; diisopropylamine; calcium carbonate; In tetrahydrofuran; methanol; ethanol; hexane; water; ethylene glycol; toluene;
DOI:10.1248/cpb.33.5316