(4S,5R)-(-)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

Base Information

• Chemical Name: (4S,5R)-(-)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester
• CAS No.: 56151-96-3
• Molecular Formula: C₂₁H₃₁NO₅
• Molecular Weight: 377.481

Synonyms:(4S,5R)-(-)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

Chemical Property of (4S,5R)-(-)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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Technology Process of (4S,5R)-(-)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

There total 44 articles about (4S,5R)-(-)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(4S,5R)-1-<2-(3,4-dimethoxyphenyl)-2-hydroxyethyl>-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester (71333-94-3,71333-95-4,75821-61-3,109785-71-9,109785-72-0,115075-65-5,115075-66-6) → (4S,5R)-(-)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester (56151-96-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In perchloric acid; ethanol; for 20h; under 3040 Torr; Ambient temperature;

DOI:10.1016/S0040-4020(01)83119-7

Reference yield: 91.0%

(+/-)-trans-1-<2-(3,4-dimethoxyphenyl)-2-hydroxyethyl>-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester (71333-94-3,71333-95-4,75821-61-3,109785-71-9,109785-72-0,115075-65-5,115075-66-6) → (+/-)-trans-1-(3,4-dimethoxyphenethyl)-2-ethyl-2-oxo-4-piperidineacetic acid ethyl ester (56151-96-3,56152-02-4,71358-38-8,74036-03-6,102706-88-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In perchloric acid; ethanol; Ambient temperature;

DOI:10.1248/cpb.34.496

Reference yield: 91.0%

1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidinemalonic acid diethyl ester (78867-74-0,89681-00-5,107343-23-7) → (+/-)-trans-1-(3,4-dimethoxyphenethyl)-2-ethyl-2-oxo-4-piperidineacetic acid ethyl ester (56151-96-3,56152-02-4,71358-38-8,74036-03-6,102706-88-7)

Guidance literature:

With water; magnesium chloride; In dimethyl sulfoxide; Heating;

upstream raw materials:

(4S,5R)-1-<2-(3,4-dimethoxyphenyl)-2-hydroxyethyl>-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

(3R,4S)-1-<2-(3,4-dimethoxyphenyl)-2-hydroxyethyl>-3-ethyl-4-piperidineacetic acid ethyl ester

cinchonine

(3R,4S)-(+)-1-(3,4-dimethoxyphenacyl)-3-ethyl-4-piperidineacetic acid ethyl ester

Downstream raw materials:

(4S,5R)-(-)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid

(3R,4R)-(+)-1-(3,4-dimethoxyphenethyl)-3-ethyl-4-piperidineethanol

(4R,5R)-(+)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid

(4R,5R)-(+)-1-(3,4-dimethoxyphenethyl)-5-ethyl-2-oxo-4-piperidineacetic acid ethyl ester

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