Acridin-4-ol

Base Information

• Chemical Name: Acridin-4-ol
• CAS No.: 18123-20-1
• Molecular Formula: C13H9 N O
• Molecular Weight: 195.221
• Hs Code.: 2933990090
• European Community (EC) Number: 242-013-6
• DSSTox Substance ID: DTXSID40171086
• Nikkaji Number: J260.880D
• Wikidata: Q83041135
• Mol file: 18123-20-1.mol

Synonyms:4-hydroxyacridine

Chemical Property of Acridin-4-ol

Chemical Property:

• Vapor Pressure: 1.57E-07mmHg at 25°C
• Melting Point: 114-118 °C
• Boiling Point: 416.6°Cat760mmHg
• PKA: 7.89±0.30(Predicted)
• Flash Point: 205.7°C
• PSA: 33.12000
• Density: 1.307g/cm³
• LogP: 3.09360
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 195.068413911
• Heavy Atom Count: 15
• Complexity: 231

Purity/Quality:

99% ^*data from raw suppliers

Acridin-4-ol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=C3C=CC=C(C3=N2)O

Technology Process of Acridin-4-ol

There total 11 articles about Acridin-4-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.3%

4-methoxyacridine (3295-61-2) → 4-hydroxyacridine (18123-20-1)

Guidance literature:

With hydrogen bromide;

Reference yield: 24.5%

4-ethoxyacridine (428848-28-6) → 4-hydroxyacridine (18123-20-1)

Guidance literature:

With hydrogen bromide; In water; for 4h; Radiolysis;

DOI:10.1039/d0nj04753h

Reference yield:

4-aminoacridine (578-07-4) → 4-hydroxyacridine (18123-20-1)

Guidance literature:

With hydrogenchloride; water; at 200 ℃;

DOI:10.1039/jr9430000458

upstream raw materials:

4-aminoacridine

4-methoxyacridine

4-methoxy-9(10H)-acridone

Acridine 3,4-oxide

Downstream raw materials:

4-aminoacridine

C₃₄H₂₃N₃OPd

Refernces

• 1、 Shao, Tai-Ming,Wei, Zu-Zhuang,Luo, Xiao-Ling,Qin, Qi-Pin,Tan, Ming-Xiong,Zeng, Jia-Jing,Liang, Chun-Jie,Liang, Hong. "High cytotoxic and apoptotic effects of platinum(ii) complexes bearing the 4-acridinol ligand". . p. 19885 - 19890. Retrieved 2020.
• 2、 Brivio, Massimiliano,Huigens, Robert W.,Jin, Shouguang,Kim, Young S.,Liu, Ke,Norwood, Verrill M.,Papagni, Antonio,Vaghi, Luca,Xiao, Tao. "Modular Synthetic Routes to Fluorine-Containing Halogenated Phenazine and Acridine Agents That Induce Rapid Iron Starvation in Methicillin-Resistant Staphylococcus aureus Biofilms". . p. 280 - 295. Retrieved 2022/02/14.
• 3、 -. "Acridine derivatives and metal complexes thereof used for transparent recording medium or optical recording medium". . . Retrieved 2008/06/13.