(4-CHLORO-3-METHOXYPHENYL)BORONICACID

Base Information

• Chemical Name: (4-CHLORO-3-METHOXYPHENYL)BORONICACID
• CAS No.: 89694-47-3
• Molecular Formula: C7H8BClO3
• Molecular Weight: 186.403
• Hs Code.: 2931900090
• Mol file: 89694-47-3.mol

Synonyms:4-chloro-3-methoxyphenylboronic acid;4-chloro-3-methoxybenzeneboronic acid;4-Chlor-3-methoxy-benzol-boronsaeure;[4-chloro-3-(methyloxy)phenyl]boronic acid;

Chemical Property of (4-CHLORO-3-METHOXYPHENYL)BORONICACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 151°C(lit.)
• Boiling Point: 341.651oC at 760 mmHg
• PKA: 7.91±0.10(Predicted)
• Flash Point: 160.425oC
• PSA: 49.69000
• Density: 1.325g/cm3
• LogP: 0.02840
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: soluble in Methanol

Purity/Quality:

97% ^*data from raw suppliers

4-Chloro-3-methoxyphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloro-3-methoxyphenylboronic acid

Technology Process of (4-CHLORO-3-METHOXYPHENYL)BORONICACID

There total 6 articles about (4-CHLORO-3-METHOXYPHENYL)BORONICACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

5-Bromo-2-chloroanisole (16817-43-9) → (4-chloro-3-methoxyphenyl)boronic acid (89694-47-3)

Guidance literature:

5-Bromo-2-chloroanisole; With n-butyllithium; In tetrahydrofuran; hexane; toluene; at -78 ℃; for 0.5h;

With Trimethyl borate; In tetrahydrofuran; hexane; toluene; at -78 - 20 ℃;

With hydrogenchloride; In tetrahydrofuran; hexane; water; toluene;

Reference yield: 31.0%

Trimethyl borate (121-43-7,63156-11-6) + 5-Bromo-2-chloroanisole (16817-43-9) → (4-chloro-3-methoxyphenyl)boronic acid (89694-47-3)

Guidance literature:

5-Bromo-2-chloroanisole; With n-butyllithium; In tetrahydrofuran; toluene; at -78 ℃; for 0.5h; Inert atmosphere;

Trimethyl borate; In tetrahydrofuran; toluene; at 20 ℃; for 16h;

With hydrogenchloride; water; In tetrahydrofuran; toluene;

Reference yield:

Trimethyl borate (121-43-7,63156-11-6) + 4-bromo-2-chloro-1-methoxybenzene (50638-47-6) → (4-chloro-3-methoxyphenyl)boronic acid (89694-47-3)

Guidance literature:

4-bromo-2-chloro-1-methoxybenzene; With n-butyllithium; In tetrahydrofuran; toluene; at -78 ℃; for 0.5h;

Trimethyl borate; In tetrahydrofuran; toluene; at -78 - 20 ℃; for 0.25h;

With hydrogenchloride; water; In tetrahydrofuran; ethyl acetate; toluene;

upstream raw materials:

5-Bromo-2-chloroanisole

Trimethyl borate

4-bromo-2-chloro-1-methoxybenzene

2-Chloroanisole

Downstream raw materials:

(4-amino-benzyl)-carbamic acid tert-butyl ester

2-(1-(4-amino-3-(4-chloro-3-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one

2-(1-(4-amino-3-(4-chloro-3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-3-(3-fluorophenyl)-4H-chromen-4-one

C₁₁H₈Cl₂N₂O