{2-[2-(4-Chlorophenyl)ethenyl]-5-methyl-1,3-oxazol-4-yl}methanol

Base Information

Chemical Name:{2-[2-(4-Chlorophenyl)ethenyl]-5-methyl-1,3-oxazol-4-yl}methanol
CAS No.:89723-99-9
Molecular Formula:C₁₃H₁₂ClNO₂
Molecular Weight:249.697
Hs Code.:
DSSTox Substance ID:DTXSID10709294

Synonyms:DTXSID10709294;{2-[2-(4-Chlorophenyl)ethenyl]-5-methyl-1,3-oxazol-4-yl}methanol

Suppliers and Price of {2-[2-(4-Chlorophenyl)ethenyl]-5-methyl-1,3-oxazol-4-yl}methanol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of {2-[2-(4-Chlorophenyl)ethenyl]-5-methyl-1,3-oxazol-4-yl}methanol

Chemical Property:

XLogP3:2.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:249.0556563
Heavy Atom Count:17
Complexity:264

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=C(N=C(O1)C=CC2=CC=C(C=C2)Cl)CO

Technology Process of {2-[2-(4-Chlorophenyl)ethenyl]-5-methyl-1,3-oxazol-4-yl}methanol

There total 6 articles about {2-[2-(4-Chlorophenyl)ethenyl]-5-methyl-1,3-oxazol-4-yl}methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.4%

: 89723-99-9
2-(4-Chlorostyryl)-4-hydroxymethyl-5-methyloxazole

Guidance literature:

Reference yield:

: 2-[(E)-2-(4-Chloro-phenyl)-vinyl]-5-methyl-oxazole-4-carbonyl chloride

: 89723-99-9
2-(4-Chlorostyryl)-4-hydroxymethyl-5-methyloxazole

Guidance literature:: With hydrogenchloride; sodium tetrahydroborate; In 1,2-dimethoxyethane; Yield given; ice cooling 30 min, reflux 30 min;
DOI:10.1248/cpb.34.2840

Reference yield:

: 35086-79-4,95602-71-4
cinnamoyl chloride

: 89723-99-9
2-(4-Chlorostyryl)-4-hydroxymethyl-5-methyloxazole

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / CHCl₃

2: POCl₃ / 0.5 h / 100 - 110 °C

3: 89.8 percent / 2N NaOH / ethanol / 0.25 h / 90 deg C bath

4: SOCl₂ / 1 h / Heating

5: NaBH₄, 2N HCl / 1,2-dimethoxy-ethane / ice cooling 30 min, reflux 30 min

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; triethylamine; trichlorophosphate; In 1,2-dimethoxyethane; ethanol; chloroform;
DOI:10.1248/cpb.34.2840