6-METHYL-6,11-DIHYDRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE

Base Information

Chemical Name:6-METHYL-6,11-DIHYDRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE
CAS No.:16287-28-8
Molecular Formula:C13H11 N3 O
Molecular Weight:225.2459
Hs Code.:
Mol file:16287-28-8.mol

Synonyms:6-methyl-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one;N6-Methyl-6,11-dihydro-5H-pyrido(2,3-b)(1,5)benzodiazepin-5-one;6-methyl-6,11-dihydro-benzo[b]pyrido[2,3-e][1,4]diazepin-5-one;5H-Pyrido(2,3-b)(1,5)benzodiazepin-5-one,6,11-dihydro-6-methyl;6,11-dihydro-6-methyl-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one;

Suppliers and Price of 6-METHYL-6,11-DIHYDRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
6-METHYL-6,11-DIHYDRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE 95.00%
10MG
$ 736.14

American Custom Chemicals Corporation
6-METHYL-6,11-DIHYDRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE 95.00%
5MG
$ 730.54

American Custom Chemicals Corporation
6-METHYL-6,11-DIHYDRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE 95.00%
1MG
$ 688.84

Total 0 raw suppliers

Chemical Property of 6-METHYL-6,11-DIHYDRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE

Chemical Property:

Vapor Pressure:4.52E-08mmHg at 25°C
Boiling Point:443.7°Cat760mmHg
Flash Point:222.2°C
PSA：50.68000
Density:1.247g/cm³
LogP:1.97700

Purity/Quality:: 6-METHYL-6,11-DIHYDRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 6-METHYL-6,11-DIHYDRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE

There total 10 articles about 6-METHYL-6,11-DIHYDRO-5H-PYRIDO[2,3-B][1,5]BENZODIAZEPIN-5-ONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 39778-17-1
1-methyl-3-(pyridin-2-yl)-1H-benzo[d]imidazol-3-ium iodide

: 16287-28-8
6-methyl-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one

Guidance literature:: With silver carbonate; In tetrahydrofuran; at 20 - 70 ℃; for 24h;
DOI:10.1002/chem.201905828

Reference yield: 42.0%

: 826991-86-0
N-(2-amino-phenyl)-2-chloro-N-methyl-pyridine-3-carboxamide

: 16287-28-8
6-methyl-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one

Guidance literature:: With potassium tert-butylate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In toluene; for 48h; Heating;
DOI:10.1016/j.tet.2004.10.061

Reference yield:

: 63069-48-7
p-chloro-o-iodoaniline

: 16287-28-8
6-methyl-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / triethylamine / CH₂Cl₂ / 5 h / 20 °C

2: 88 percent / NaOH; K₂CO₃; tetrabutylammonium hydrogen sulphate / benzene / 12 h / 70 - 80 °C

3: 92 percent / AcOH; Fe dust / ethanol / 5 h / Heating

4: 42 percent / t-BuOK; BINAP / Pd(OAc)2 / toluene / 48 h / Heating

With sodium hydroxide; potassium tert-butylate; tetra(n-butyl)ammonium hydrogensulfate; iron; potassium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; triethylamine; palladium diacetate; In ethanol; dichloromethane; toluene; benzene; 4: Buchwald-Hartwig amination;
DOI:10.1016/j.tet.2004.10.061