4H-1-Benzothiopyran-2-butanoic acid, 6-chloro-b-(2,4-dichlorophenyl)-3-hydroxy-4-oxo-, 1,1-dioxide

Base Information

Chemical Name:4H-1-Benzothiopyran-2-butanoic acid, 6-chloro-b-(2,4-dichlorophenyl)-3-hydroxy-4-oxo-, 1,1-dioxide
CAS No.:89756-82-1
Molecular Formula:C19H13Cl3O6S
Molecular Weight:475.72700
Hs Code.:

Synonyms:4-(6-Chloro-3-hydroxy-1,1,4-trioxo-1,4-dihydro-1λ6-thiochromen-2-yl)-3-(2,4-dichloro-phenyl)-butyric acid;

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4H-1-Benzothiopyran-2-butanoic acid, 6-chloro-b-(2,4-dichlorophenyl)-3-hydroxy-4-oxo-, 1,1-dioxide

Chemical Property:

Boiling Point:706.4±60.0 °C(Predicted)
PSA：117.12000
Density:1.651±0.06 g/cm3(Predicted)
LogP:6.11580

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4H-1-Benzothiopyran-2-butanoic acid, 6-chloro-b-(2,4-dichlorophenyl)-3-hydroxy-4-oxo-, 1,1-dioxide

There total 5 articles about 4H-1-Benzothiopyran-2-butanoic acid, 6-chloro-b-(2,4-dichlorophenyl)-3-hydroxy-4-oxo-, 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 89756-72-9
7-chloro-3-(2,4-dichlorophenyl)-3,4-dihydro-1H-thioxanthene-1,9(2H)dione

: 89756-82-1
6-chloro-β-(2,4-dichlorphenyl)-3-hydroxy-4-oxo-4H-1-benzothiopyran-2-butanoic acid 1,1-dioxide

Guidance literature:: With dihydrogen peroxide; In trifluoroacetic acid; at 0 ℃; for 72h;
DOI:10.1002/jhet.5570200628

Reference yield:

: 20324-50-9
5-chloro-2-mercapto-benzoic acid

: 89756-82-1
6-chloro-β-(2,4-dichlorphenyl)-3-hydroxy-4-oxo-4H-1-benzothiopyran-2-butanoic acid 1,1-dioxide

Guidance literature:: Multi-step reaction with 3 steps

1: NaH (50percent dispersion in mineral oil) / dimethylformamide / 2 h / Ambient temperature

2: 51 percent / polyphosphoric acid / 72 h / 90 °C

3: 63 percent / 30percent aq. H₂O₂ / trifluoroacetic acid / 72 h / 0 °C

With PPA; dihydrogen peroxide; sodium hydride; In N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1002/jhet.5570200628

Reference yield:

: 5-(2,4-dichlorophenyl)-1,3-cyclohexanedione

: 89756-82-1
6-chloro-β-(2,4-dichlorphenyl)-3-hydroxy-4-oxo-4H-1-benzothiopyran-2-butanoic acid 1,1-dioxide

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / PBr₃ / CH₂Cl₂ / 2 h / Heating

2: NaH (50percent dispersion in mineral oil) / dimethylformamide / 2 h / Ambient temperature

3: 51 percent / polyphosphoric acid / 72 h / 90 °C

4: 63 percent / 30percent aq. H₂O₂ / trifluoroacetic acid / 72 h / 0 °C

With PPA; dihydrogen peroxide; phosphorus tribromide; sodium hydride; In dichloromethane; N,N-dimethyl-formamide; trifluoroacetic acid;
DOI:10.1002/jhet.5570200628