20324-50-9

Usage

Uses

Used in Pharmaceutical Synthesis:
5-CHLORO-2-MERCAPTOBENZOIC ACID is utilized as an intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows for the development of new drugs with potential therapeutic benefits.
Used in Agrochemical Production:
5-CHLORO-2-MERCAPTOBENZOIC ACID is also employed in the production of agrochemicals, contributing to the development of effective pesticides and other agricultural products.
Used in Antioxidant Research:
5-CHLORO-2-MERCAPTOBENZOIC ACID has been studied for its potential antioxidant properties. It is used in research to understand its ability to combat oxidative stress, which can lead to various health issues.
Used in Antimicrobial Applications:
5-CHLORO-2-MERCAPTOBENZOIC ACID has demonstrated antimicrobial properties, making it a valuable tool in the development of new antimicrobial agents to combat resistant bacteria and other pathogens.
Used in Oxidative Stress and Inflammation Studies:
5-CHLORO-2-MERCAPTOBENZOIC ACID is used in research to study the effects of oxidative stress and inflammation on biological systems. Its unique properties allow for a better understanding of these processes and the development of potential treatments.

Upstream product

• 69135-70-2 2,2'-dithiobis<5-chlorobenzoic acid> 
• 38244-31-4 5-chloro-2-mercaptobenzonitrile 
• 57381-34-7 5-chloro-2-fluorobenzonitrile 
• 88279-11-2 2-carboxy-4-chlorophenyl azide 
• 4068-78-4 methyl 5-chloro-2-hydroxybenzoate 
• 140-89-6 potassium ethyl xanthogenate 
• 635-21-2 5-chloroanthranilic acid 

Downstream Products

• 25697-91-0 5-Chloro-2-(4-chloro-benzylsulfanyl)-benzoic acid 
• 66949-65-3 2-(4-Acetylphenylthio)-5-chlorbenzoesaeure 
• 198897-07-3 5-Chloro-2-(2-methylcarbamoyl-phenylsulfanyl)-benzoic acid 
• 1020412-76-3 5-chloro-2-(4-ethoxycarbonyl-2-nitrophenylthio)benzoic acid 
• 198897-03-9 5-Chloro-2-(2-methylcarbamoyl-benzenesulfinyl)-benzoic acid 
• 4700-07-6 5-chloro-2-mercaptobenzophenone 
• 25697-89-6 5-Chloro-2-(3-trifluoromethyl-benzylsulfanyl)-benzoic acid 
• 25697-90-9 5-Chloro-2-(3-nitro-benzylsulfanyl)-benzoic acid 
• 25697-88-5 2-(benzylthio)-5-chlorobenzoic acid 
• 79003-44-4 α-[(2-carboxy-4-chlorophenyl)thio]-γ-butyrolactone 
• 52948-10-4 5-chloro-2-mercapto-benzoic acid methyl ester 
• 69135-70-2 2,2'-dithiobis<5-chlorobenzoic acid> 
• 712302-46-0 2-(benzhydrylthio)benzoic acid 

Relevant academic research and scientific papers

Chemical synthesis, crystal structure, versatile evaluation of their biological activities and molecular simulations of novel pyrithiobac derivatives

Since pyrithiobac (PTB) is a successful commercial herbicide with very low toxicity against mammals, it is worth exploring its derivatives for an extensive study. Herein, a total of 35 novel compounds were chemically synthesized and single crystal of 6–6

Scaffold Diversity Inspired by the Natural Product Evodiamine: Discovery of Highly Potent and Multitargeting Antitumor Agents

A critical question in natural product-based drug discovery is how to translate the product into drug-like molecules with optimal pharmacological properties. The generation of natural product-inspired scaffold diversity is an effective but challenging strategy to investigate the broader chemical space and identify promising drug leads. Extending our efforts to the natural product evodiamine, a diverse library containing 11 evodiamine-inspired novel scaffolds and their derivatives were designed and synthesized. Most of them showed good to excellent antitumor activity against various human cancer cell lines. In particular, 3-chloro-10-hydroxyl thio-evodiamine (66c) showed excellent in vitro and in vivo antitumor efficacy with good tolerability and low toxicity. Antitumor mechanism and target profiling studies indicate that compound 66c is the first-in-class triple topoisomerase I/topoisomerase II/tubulin inhibitor. Overall, this study provided an effective strategy for natural product-based drug discovery. (Figure Presented).

HETEROCYCLIC DERIVATIVE HAVING INHIBITORY ACTIVITY ON TYPE-I 11 -HYDROXYSTEROID DEHYDROGENASE

Disclosed is a compound which is useful as an 11β-hydroxysteroid dehydrogenase type 1 inhibitor. A compound represented by the formula: its pharmaceutically acceptable salt, or a solvate thereof, wherein X is O or S, a broken line and a wavy line represent the presence or the absence of a bond, (i) when a broken line represents the presence of a bond, a wavy line represents the absence of a bond, R2 and R3 are each independently hydrogen, halogen, cyano, hydroxy, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or the like, (ii) when a broken line represents the absence of a bond, a wavy line represents the presence of a bond, R1 and R4 are each independently hydrogen, halogen or the like, R2 and R3 are each independently hydrogen, halogen, cyano, hydroxy, carboxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or the like, and R5 and R6 are each independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl or the like.

USE OF CANNABINOID MODULATING COMPOUNDS IN COMBINATION WITH OTHER THERAPEUTIC COMPOUNDS FOR ADJUNCTIVE THERAPY

The present invention relates to pharmaceutical compositions that contain a compound that modulate the activity of a cannabinoid receptor in conjunction with another therapeutic compound and uses of compounds that modulate the activity of a cannabinoid re

Substituent effects on the reactivity of benzo-1,2-dithiolan-3-one 1-oxides and their possible application to the synthesis of DNA-targeting drugs

The efficiency of polysulfane product generation has been investigated for n-propyl thiol reactions with ortho- and para-substituted benzo-1,2-dithiolan-3- one 1-oxides in acetonitrile-water (7:3) mixtures. The reaction is facilitated by reducing the electron density at the para position or by placing substituents bearing lone pair electrons ortho to the dithiolanone-oxide (S1) reaction center. Through-space and through-bond effects both contribute to the conversion of polysulfane products.

Synthesis of some 4-oxothiochromenes and related compounds

Thiosalicylic acids react with 2-substituted N,N-dialkyl acetamides to give 3-substituted-N,N-dialkyl-2-amino-4-oxothiochromenes 13. N-Alkyl 2-piperidone and analogous caprolactams give derivatives of 1,2,3,4-tetrahydrothiochromeno[2, 3-b]pyridin-5-one 16

Novel inhibitors of the prenylated protein methyltransferase reveal distinctive structural requirements

Inhibitors of a prenylated protein methyltransferase were synthesized and evaluated. S-farnesyl-5-fluorothiosalicylic acid and the 5-chloro analog (but not the 4-fluoro, 4-chloro or 3-chloro analogs) were potent inhibitors, as was the parent compound S-farnesyl thiosalicylic acid (FTS), whose methyl ester was far less active. S-geranyl and S-geranylgeranyl thiosalicylic acids were more than ten times less potent than FTS.