1-[2-Phenyl-5-(pyridin-3-yl)-1,3,4-oxadiazol-3(2H)-yl]ethan-1-one

Base Information

Chemical Name:1-[2-Phenyl-5-(pyridin-3-yl)-1,3,4-oxadiazol-3(2H)-yl]ethan-1-one
CAS No.:89813-90-1
Molecular Formula:C15H13N3O2
Molecular Weight:267.287
Hs Code.:
ChEMBL ID:CHEMBL2261548
DSSTox Substance ID:DTXSID50520021

Synonyms:89813-90-1;CHEMBL2261548;DTXSID50520021;1-[2-Phenyl-5-(pyridin-3-yl)-1,3,4-oxadiazol-3(2H)-yl]ethan-1-one

Suppliers and Price of 1-[2-Phenyl-5-(pyridin-3-yl)-1,3,4-oxadiazol-3(2H)-yl]ethan-1-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-[2-Phenyl-5-(pyridin-3-yl)-1,3,4-oxadiazol-3(2H)-yl]ethan-1-one

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:267.100776666
Heavy Atom Count:20
Complexity:391

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)N1C(OC(=N1)C2=CN=CC=C2)C3=CC=CC=C3

Technology Process of 1-[2-Phenyl-5-(pyridin-3-yl)-1,3,4-oxadiazol-3(2H)-yl]ethan-1-one

There total 5 articles about 1-[2-Phenyl-5-(pyridin-3-yl)-1,3,4-oxadiazol-3(2H)-yl]ethan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 1081819-52-4
N'-(phenylmethylidene)pyridine-3-carbohydrazide

: 108-24-7
acetic anhydride

: 89813-90-1
1-(2-phenyl-5-(pyridin-3-yl)-1,3,4-oxadiazole-3(2H)-yl)ethanone

Guidance literature:: for 1h; Reflux;
DOI:10.1007/s00044-010-9489-9

Reference yield: 60.0%

: 17336-46-8
(E)-N’-benzylidenenicotinohydrazide

: 108-24-7
acetic anhydride

: 89813-90-1
1-(2-phenyl-5-(pyridin-3-yl)-1,3,4-oxadiazole-3(2H)-yl)ethanone

Guidance literature:: for 1h; Heating;

Reference yield:

: 10400-19-8
3-pyridinecarbonyl chloride

: 89813-90-1
1-(2-phenyl-5-(pyridin-3-yl)-1,3,4-oxadiazole-3(2H)-yl)ethanone

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / 5 h / 0 °C

2: tetrahydrofuran / 2 h / 60 °C

3: ethanol / 2 h / Reflux

With hydrazine hydrate; In tetrahydrofuran; ethanol;
DOI:10.1007/s00044-017-2098-0