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10400-19-8 Usage


Nicotinyl Chloride can be used to treat hyperthyroidism.

Check Digit Verification of cas no

The CAS Registry Mumber 10400-19-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,0,4,0 and 0 respectively; the second part has 2 digits, 1 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 10400-19:
38 % 10 = 8
So 10400-19-8 is a valid CAS Registry Number.



According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017


1.1 GHS Product identifier

Product name pyridine-3-carbonyl chloride

1.2 Other means of identification

Product number -
Other names (pyridin-3-yl)-carbonyl chloride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:10400-19-8 SDS

10400-19-8Relevant articles and documents

Catalytic and electrocatalytic wet oxidation of phenol using two new nickel(II) tetraazamacrocycle complexes under heterogeneous conditions

Bansal, Vipin Kumar,Thankachan, Pompozhi Protasis,Prasad, Rajendra

, p. 131 - 138 (2010)

Two new tetraazamacrocycle complexes, namely, 7,16-dinicotinoyl[Ni{Me4(4-MeBzo)2[14]tetraeneN4}] and 7,16-diisonicotinoyl[Ni{Me4(4-MeBzo)2[14]tetraeneN4}] (where [Ni{Me4(4-MeBzo)

Palladium(II)-catalysed oxidation of alcohols under an oxygen atmosphere in a fluorous biphase system (FBS)

Nishimura, Takahiro,Maeda, Yasunari,Kakiuchi, Nobuyuki,Uemura, Sakae

, p. 4301 - 4305 (2000)

Palladium(II) acetate catalyses the aerobic oxidation of alcohols into the corresponding aldehydes and ketones in the presence of a catalytic amount of a novel perfluoroalkylated-pyridine as a ligand using molecular oxygen in a fluorous biphase system (FBS) composed of toluene and perfluorodecalin. This catalytic system is applicable to various benzylic and aliphatic alcohols. The fluorous phase containing the active palladium species is easily separated and can be reused several times without a significant loss of catalytic activity. The Royal Society of Chemistry 2000.

Crystal structure and energy optimization of dichlorobis(ethylanthranilatonicotinamide)zinc(II)

Narayanan, Venkatraj V.,Gopalan, R. Srinivasa,Chakrabarty, Debojit,Mobin, Shaikh M.,Mathur, Pradeep

, p. 801 - 805 (2011)

The title compound, C30H28Cl2N 4O6Zn, dichlorobis(ethylanthranilatonicotinamide)zinc(II) crystallized in a triclinic space group, P - 1, with cell parameters a = 7.787(3), b = 13.468(1), c = 15.735(1)

Anion templated surface assembly of a redox-active sensory rotaxane

Bayly, Simon R.,Gray, Thomas M.,Chmielewski, Michal J.,Davis, Jason J.,Beer, Paul D.

, p. 2234 - 2236 (2007)

Anion templation is used to assemble novel redox-active bis-ferrocene functionalised rotaxane self-assembled monolayers (SAMs) on to gold electrode surfaces; after template removal, the unique SAM rotaxane binding domain is capable of selectively sensing chloride ions electrochemically. The Royal Society of Chemistry.

Fluorescent hydrogels formed by CH-π and π-π Interactions as the main driving forces: An approach toward understanding the relationship between fluorescence and structure

Ahn, Jinho,Park, Sunhong,Lee, Ji Ha,Jung, Sung Ho,Moon, Seung-Jin,Jung, Jong Hwa

, p. 2109 - 2111 (2013)

Amide-linked tripyridine derivatives 1, with a para-substituent, and 2, with a meta-substituent, were gelated in water or water-DMSO. The gelation capabilities of 1 and 2 were attributed to the cooperative effects of mainly CH-π and π-π stacking or strong intermolecular hydrogen bonding interactions between the amide groups. The fluorescence properties of gels 1 and 2 were dependent on the binding strength of the π-π stacking.

Polymeric complexes with "piperazine-pyridine" building blocks: Synthesis, network structures, and third-order nonlinear optical properties

Hou, Hongwei,Song, Yinglin,Xu, Hong,Wei, Yongli,Fan, Yaoting,Zhu, Yu,Li, Linke,Du, Chenxia

, p. 999 - 1008 (2003)

A new bidentate "building block", N,N′-bis(3-pyridylformyl)piperazine (bpfp), was synthesized. X-ray diffraction studies reveal that the piperazine ring in bpfp forms a chairlike structure conformation, bpfp self-assembled into two-dimensional layered rhombohedral grid polymers {[Mn(H2O)2(SO4)(bpfp)](H2O)3 (CH3OH)}n (1) and {[Zn(NCS)2(bpfp)2]·2H2O}n (2) with Mn(II) and Zn(II), a three-dimensional polymer [Cd(N3)2(bpfp)]n (3) with Cd(II), and a one-dimensional zigzag polymer [HgI2(bpfp)]n (4) with Hg(II). Each rhombohedral grid in polymer 1 is composed of four Mn, two bpfp, and two SO42-; the dimensions of the grid are 6.537 × 12.843 A. In polymer 2, each rhombohedral grid consists of 60-membered rings Zn4(bpfp)4 showing the dimensions of 14.231 × 15.586 A. Zn4(bpfp)4 grids are bridged by Zn ions and all pyridyl-N atoms of bpfp ligands into the 2-D network structure along a and c directions. Polymer 3 exhibits a 3-D layered structure with tetragonal prism channel viewing from a direction. The bpfp ligands occupy the four edges of tetragonal prism channel, which is cut off by layers consisting of rhombohedral grids Cd4(N3)4. Polymer 4 is quite different from polymers 1-3; it exhibits a 1-D zigzag framework extending along the c axis. Polymers 1-3 possess a very strong NLO absorption and self-focusing effect. Their third-order NLO absorptive coefficients α2 are 9.2 × 10-9, 6.9 × 10-9, and 7.1 × 10-9 m W-1. The third-order NLO hyperpolarizabilities γ are 1.79 × 10-28, 9.10 × 10-29, and 9.66 × 10-29 esu, respectively. The γ values are comparable to those of the best NLO materials and coordination polymers. We found that the valence shell structures of central metal ions can influence the NLO properties of coordination polymers.

Phase transfer-catalyzed, one-pot synthesis of some novel N-pyrimidinyl-N'-nicotinyl thiourea derivatives

Liu, Xing-Hai,Tan, Cheng-Xia,Weng, Jian-Quan

, p. 552 - 557 (2011)

A new series of acyl thiourea derivatives were synthesized in one-pot using PEG-600 as the phase transfer catalyst (PTC). The structures of title compounds were characterized by 1H NMR, IR, MS, and elemental analysis. In addition, the fungicidal activity of the acyl thiourea derivatives were tested, which showed that most of them exhibit moderate activity. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements to view the free supplemental file. Copyright Taylor & Francis Group, LLC.

Design, synthesis, and vasorelaxation activity of novel imperatorin derivatives

Zhou, Nan,He, Jian-Yu,Wang, Tao,Zhang, Jie,He, Huai-Zhen

, p. 650 - 657 (2013)

In this study, a series of novel imperatorin derivatives 7a-7e were designed and synthesized. Their vasorelaxation activities were evaluated by the pharmacological experiments in vitro. Most of the tested compounds exhibited better water solubility and vasorelaxation activity in different degrees, especially 7b and 7c with EC50 values of 2.29 and 2.63 μM, respectively on mesenteric artery, 7d and 7e with EC50 values of 1.04 and 2.65 μM, respectively on brain artery. The results indicated that these novel compounds have a potential interest for the development of novel and potent vasorelaxant agents for different kinds of arteries.


Wingfield et al.

, p. 4364 (1953)


Pseudocryptand Hosts for Paraquats and Diquats

Jones, Jason W.,Price, Terry L.,Huang, Feihe,Zakharov, Lev,Rheingold, Arnold L.,Slebodnick, Carla,Gibson, Harry W.

, p. 823 - 834 (2018)

H-bonding interaction of acidic moieties (CH2OH, COOH) at the 5- and 5′-positions of bis(1,3-phenylene)-32-crown-10 (1) with di- or tritopic anions leads to enhanced formation of inclusion complexes with N,N′-dialkyl-4,4′-bipyridinium salts ("paraquats", 2); the enforced folding of the crown ethers into pseudocryptands thus leads to pseudo-pseudorotaxanes. Strikingly, in the presence of the most effective anion (trifluoroacetate, TFA), the apparent bimolecular association constants for crown-paraquat complexation increase by more than an order of magnitude and approach those for covalent cryptands derived from the crown ether. Even though they may form pseudocryptands, the picolinate, nicotinate, and isonicotinate diesters 6 of cis-(4,4')-bis(hydroxymethyl)dibenzo-30-crown-10 do not exhibit enhanced binding of either diquat or paraquat relative to the starting diol in contrast to the picolinate ester of isomeric 5,5′-bis(hydroxymethyl)bis(m-phenylene)-32-crown-10, which displayed a higher binding constant than the starting diol. The results for the analogous reverse esters 7 derived from cis-(4,4')-dicarboxydibenzo-30-crown-10 and pyridylmethanols reveal weaker complexes with diquat than the normal esters 6; however, surprisingly, two reverse esters 7 complex paraquat more strongly than isomers 6.

Synthesis of sugar modified nucleosides containing nicotinic, quinaldic, indol-3-ylpropionic or 1-nitroanthraquinone-2-carboxylic acid residue


, p. 377 - 380 (1995)

The nucleoside derivatives were synthesized with arylcarbonic acid residue as an anchor group at the sugar moiety coupled by an ester or an amide bond. Their cytotoxic properties and effects on DNA structure were studied.

Prodrug compound and application thereof in treatment of cancer


Paragraph 0132-0133, (2021/03/06)

The present invention provides a compound indicated by a formula (I), pharmaceutically acceptable salts or esters thereof, a pharmaceutical composition of the compound, and the use of the compound andthe pharmaceutical composition in inhibition or regulation of tyrosine kinase activity, and treatment of tyrosine kinase mediated disease symptoms or disorders including cancer.

Synthesis and insecticidal activity of rotenone analogues

Zhicheng, Liu,Dingxin, Jiang,Hanhong, Xu,Xiaohua, Zheng

, p. 1063 - 1070 (2018/10/26)

Rotenone, one of traditional botanical insecticide, has been used more than one hundred years. A variety of rotenone derivatives were designed and synthesized in recent years due to environmental benign character and not easy to generate insecticide resistance. This paper described the molecular design, synthesis, and insecticidal activities of a series of rotenone analogues and 2-substituted rotenone derivatives. The preliminary bioassay showed that isorotenone and 2-rotenone nicotinate is equal to rotenone's against Musca domestica.

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