3-Phenyl-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7(1H)-one

Base Information

Chemical Name:3-Phenyl-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7(1H)-one
CAS No.:89819-57-8
Molecular Formula:C17H12N4O
Molecular Weight:288.308
Hs Code.:
DSSTox Substance ID:DTXSID20522012
Wikidata:Q82386917

Synonyms:89819-57-8;3-Phenyl-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7(1H)-one;DTXSID20522012

Suppliers and Price of 3-Phenyl-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7(1H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Phenyl-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7(1H)-one

Chemical Property:

XLogP3:1.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:288.10111102
Heavy Atom Count:22
Complexity:551

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C=C1)C2=CNN3C2=NC(=CC3=O)C4=CC=NC=C4

Technology Process of 3-Phenyl-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7(1H)-one

There total 7 articles about 3-Phenyl-5-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 5-amino-1<1'-hydroxy-3'-imino-3'-(γ-pyridyl)-propen-1-yl>-4-phenyl-pyrazole

: 89819-57-8
7-hydroxy-2-phenyl-5-(γ-pyridyl)-pyrazolo<1,5-a>pyrimidine

Guidance literature:: With hydrogenchloride; In ethanol; for 3h; Heating;

Reference yield: 78.0%

: 26377-17-3
ethyl 3-oxo-3-(4-pyridyl)propanoate

: 827-41-8
3-phenylpyrazol-5-amine

: 89819-57-8
7-hydroxy-2-phenyl-5-(γ-pyridyl)-pyrazolo<1,5-a>pyrimidine

Guidance literature:: at 160 ℃;

Reference yield:

: 26377-17-3
ethyl 3-oxo-3-(4-pyridyl)propanoate

: 89819-57-8
7-hydroxy-2-phenyl-5-(γ-pyridyl)-pyrazolo<1,5-a>pyrimidine

Guidance literature:: Multi-step reaction with 6 steps

1: 92 percent / hydroxylamine hydrochloride, sodium acetate / ethanol / 2 h / Heating

2: phosphorous oxychloride / 130 °C

3: 92.5 percent / hydrazine / 0.03 h / 100 °C

4: 62 percent / acetic acid / 2 h / Heating

5: 39 percent / H₂ / Raney nickel / ethanol / 5 h / 2585.7 Torr / Ambient temperature

6: 82 percent / hydrochloric acid / ethanol / 3 h / Heating

With hydrogenchloride; hydroxylamine hydrochloride; hydrogen; sodium acetate; hydrazine; trichlorophosphate; nickel; In ethanol; acetic acid;