2-AMINO-5-PHENYL-1 3 4-THIADIAZOLE 96

Base Information

• Chemical Name: 2-AMINO-5-PHENYL-1 3 4-THIADIAZOLE 96
• CAS No.: 2002-03-1
• Molecular Formula: C8H7 N3 S
• Molecular Weight: 177.23
• Hs Code.: 2934999090
• Mol file: 2002-03-1.mol

Synonyms:1,3,4-Thiadiazole,2-amino-5-phenyl- (6CI,7CI,8CI); 2-Amino-5-phenyl-1,3,4-thiadiazole;2-Amino-5-phenylthiadiazole; 2-Phenyl-5-amino-1,3,4-thiadiazole;5-Phenyl-1,3,4-thiadiazol-2-amine; 5-Phenyl-1,3,4-thiadiazole-2-amine;5-Phenyl-2-amino-1,3,4-thiadiazole; NSC 677

Chemical Property of 2-AMINO-5-PHENYL-1 3 4-THIADIAZOLE 96

Chemical Property:

• Vapor Pressure: 8.05E-14mmHg at 25°C
• Melting Point: 223-227 °C(lit.)
• Boiling Point: 569.8°C at 760 mmHg
• PKA: 2.90±0.10(Predicted)
• Flash Point: 298.4°C
• PSA: 80.04000
• Density: 1.333±0.06 g/cm3(Predicted)
• LogP: 2.36850
• Solubility.: soluble in Dimethylformamide

Purity/Quality:

98%,99%, ^*data from raw suppliers

5-Phenyl-1,3,4-thiadiazol-2-amine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 2-Amino-5-phenyl-1,3,4-thiadiazole may be used for the synthesis of 1,3,4-thiadiazole derivatives.

Technology Process of 2-AMINO-5-PHENYL-1 3 4-THIADIAZOLE 96

There total 62 articles about 2-AMINO-5-PHENYL-1 3 4-THIADIAZOLE 96 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

thiosemicarbazide (79-19-6) + benzonitrile (100-47-0) → 2-amino-5-phenyl-1,3,4-thiadiazole (2002-03-1)

Guidance literature:

With PPA; at 95 - 100 ℃; for 6h;

DOI:10.1007/BF00707235

Reference yield: 97.0%

thiosemicarbazide (79-19-6) + benzoic acid (65-85-0,8013-63-6) → 2-amino-5-phenyl-1,3,4-thiadiazole (2002-03-1)

Guidance literature:

With trichlorophosphate; In toluene; at 110 ℃; for 0.5h; Cooling with ice;

Reference yield: 95.0%

1-benzylidene thiosemicarbazide (1627-73-2) → 2-amino-5-phenyl-1,3,4-thiadiazole (2002-03-1)

Guidance literature:

In ethanol; for 12h; Reflux;

DOI:10.1002/jhet.2779

upstream raw materials:

1-benzylidene thiosemicarbazide

benzoyl thiosemicarbazide

5-benzoyl-pyrimidine-2,4,6-trione

thiosemicarbazide

Downstream raw materials:

2-(4-fluorobenzalamino)-5-phenyl-1,3,4-thiadiazole

(4-chloro-benzylidene)-(5-phenyl-[1,3,4]thiadiazol-2-yl)-amine

(2-chloro-benzylidene)-(5-phenyl-[1,3,4]thiadiazol-2-yl)-amine

4-[(5-phenyl-[1,3,4]thiadiazol-2-ylimino)-methyl]-phenol