1,4,7,10-TETRAAZACYCLODODECANE TETRAHYDROCHLORIDE

Base Information

• Chemical Name: 1,4,7,10-TETRAAZACYCLODODECANE TETRAHYDROCHLORIDE
• CAS No.: 10045-25-7
• Molecular Formula: C8H24Cl4N4
• Molecular Weight: 318.117
• Hs Code.: 29339900
• Mol file: 10045-25-7.mol

Synonyms:1,4,7,10-Tetraazacyclododecane, tetrahydrochloride (9CI);

Chemical Property of 1,4,7,10-TETRAAZACYCLODODECANE TETRAHYDROCHLORIDE

Chemical Property:

• Appearance/Colour: white crystalline solid
• Vapor Pressure: 0.00309mmHg at 25°C
• Melting Point: 297-300 °C
• Boiling Point: 283.8 °C at 760 mmHg
• Flash Point: 129.5 °C
• PSA: 48.12000
• LogP: 2.88160
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Hygroscopic

Purity/Quality:

99% ^*data from raw suppliers

1,4,7,10-Tetraazacyclododecane Tetrahydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Cyclen tetrahydrochloride may be used for the synthesis of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methyleneethylphosphinic acid), a new macrocyclic polyaza polyphosphinate ligand. It may also be used in the synthesis of anthraquinone-pendant cyclen.

Technology Process of 1,4,7,10-TETRAAZACYCLODODECANE TETRAHYDROCHLORIDE

There total 9 articles about 1,4,7,10-TETRAAZACYCLODODECANE TETRAHYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

cyclen-glyoxal (74199-09-0,79236-92-3) → 1,4,7,10-tetraazacyclododecane tetrahydrochloride (10045-25-7)

Guidance literature:

With hydroxylamine hydrochloride; In methanol; for 36h; Heating;

DOI:10.3891/acta.chem.scand.52-1402

Reference yield: 66.0%

cyclen tetratosylate (52667-88-6) → 1,4,7,10-tetraazacyclododecane tetrahydrochloride (10045-25-7)

Guidance literature:

With hydrogenchloride; sulfuric acid; Amberlyst A₂₆; at 120 ℃; for 48h;

DOI:10.1021/ja964319o

Reference yield:

8b-methyldecahydro-2a,4a,6a,8a-tetraazacyclopenta[fg]acenaphthylene (809289-72-3) → 1,4,7,10-tetraazacyclododecane tetrahydrochloride (10045-25-7)

Guidance literature:

With hydrogenchloride; In water; at 80 - 100 ℃; for 3h;

upstream raw materials:

cyclen tetratosylate

cyclen-glyoxal

cis-13-1,4,7,10-tetraazatetracyclo<5.5.2.0^4,140^10,13>tetradecane

triethylentetramine

Downstream raw materials:

1,4,7,10-tetraaza-cyclododecane-1,7-dicarboxylic acid dibenzyl ester

cyclen-glyoxal

phenylmethyl 2-(1,4,7,10-Tetraaza-4,7,10-tris(((tert-butyl)oxycarbonyl)methyl)cyclododecyl)-acetate

1,4,7-tris(tert-butoxycarbonylmethyl)-1,4,7,10-tetraazacyclododecane-10-acetic acid

Refernces

• 1、 Hettich, Ronald,Schneider, Hans-J?rg. "Cobalt(III) polyamine complexes as catalysts for the hydrolysis of phosphate esters and of DNA. A measurable 10 million-fold rate increase". . p. 5638 - 5647. Retrieved 1997.
• 2、 Matsumoto, Naohide,Hirano, Akira,Hara, Tadanori,Ohyoshi, Akira. "Synthesis, Characterization, and Crystal Structure Analysis of Pentane-2,4-dionato(1,4,7,10-tetra-azacyclododecane)cobalt(III) Diperchlorate Monohydrate and its Brominated Complex (3-Bromopentane-2,4-dionato)(1,4,7,10-tetra-azacyclododecane)cobalt(III) Di". . p. 2405 - 2410. Retrieved 1983.
• 3、 -. "DINUCLEATING LIGAND OR DINUCLEAR METAL COMPLEX". Paragraph 0056-0057. . Retrieved 2021/03/19.
• 4、 -. "High-efficiency environment-friendly low-cost synthetic method of cycleanine". Sheet 0039; 0040. . Retrieved 2018/04/28.