52667-88-6

Usage

Uses

Used in Electrochemistry:
1,4,7,10-TETRA-P-TOSYL-1,4,7,10-TETRAAZACYCLODODECANE is used as a modifier for the preparation of electrodes. This application is particularly relevant in studying the electrochemical behavior of nicotinamide, a vital component in biological systems and energy metabolism.
Used in Ion-Selective Electrode Preparation:
In the field of analytical chemistry, 1,4,7,10-TETRA-P-TOSYL-1,4,7,10-TETRAAZACYCLODODECANE is utilized as a key component in the development of ion-selective electrodes. Specifically, it is employed in the fabrication of coated wire chromium(III) ion-selective electrodes, which are essential tools for detecting and measuring chromium(III) ions in various samples.

Upstream product

• 56187-04-3 1,4,7-tritosyl-1,4,7-triazaheptane 
• 16695-22-0 N,N-bis(tosyloxyethyl)-p-toluenesulfonamide 
• 52601-80-6 N,N’,N”-tris(p-toluenesulfonyl)diethylenetriamine N,N-disodium salt 
• 55442-07-4 N,N',N'',N'''-tetrakis-(p-tolylsulphonyl)-triethylenetetramine 
• 106-93-4 ethylene dibromide 
• 70-55-3 toluene-4-sulfonamide 
• 97783-00-1 N,N',N-tris(p-toluenesulfonyl)-3,6,9-triazaundecane-1,11-di-p-toluenesulfonate 
• 18522-92-4 sodium p-toluenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 52601-81-7 4-Methyl-N,N-bis<2-(methylsulfonyloxy)ethyl>benzolsulfonamid 
• 112-24-3 triethylentetramine 
• 10045-25-7 1,4,7,10-tetraazacyclododecane tetrahydrochloride 
• 5469-66-9 propane-1,3-diol ditosylate 
• 134448-29-6 1,7-bis(4-toluenesulphonyl)-1,4,7,10-tetraazacyclododecane 

Downstream Products

• 60239-18-1 1,4,7,10-tetrakis(carboxymethyl)-1,4,7,10-tetraazacyclododecane 
• 175854-39-4 1,4,7-tris(tert-butyloxycarbonyl)-1,4,7,10-tetraazacyclododecane 
• 1369793-93-0 C₆₆H₁₁₀N₈O₁₄ 
• 1369793-91-8 C₆₅H₁₀₈N₈O₁₄ 
• 1369793-88-3 C₆₄H₁₀₆N₈O₁₄ 
• 1369793-87-2 C₆₃H₁₀₄N₈O₁₄ 
• 171416-77-6 1,7-dicarboxymethyl-4,10-di(p-toluenesulfonyl)-1,4,7,10-tetraazacyclododecane 
• 134448-29-6 1,7-bis(4-toluenesulphonyl)-1,4,7,10-tetraazacyclododecane 
• 294-90-6 1,4,7,10-tetraazacyclododecan 
• 112193-77-8 1,4,7,10-tetraazacyclododecanetetrasulfate 
• 10045-25-7 1,4,7,10-tetraazacyclododecane tetrahydrochloride 

Relevant academic research and scientific papers

DINUCLEATING LIGAND OR DINUCLEAR METAL COMPLEX

To provide a metal complex that has high cancer cell toxicity and has DNA target and cyclen.SOLUTION: The present disclosure provides a dinuclear metal complex represented by the following formula (IV).SELECTED DRAWING: None

BINUCLEATING LIGAND OR BINUCLEAR METAL COMPLEX

PROBLEM TO BE SOLVED: To provide a binuclear metal complex that can be easily synthesized and has a proper anticancer action. SOLUTION: The present invention provides a binuclear metal complex represented by the following chemical formula (IV). SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2018,JPOandINPIT

High-efficiency environment-friendly low-cost synthetic method of cycleanine

The invention discloses a high-efficiency environment-friendly low-cost synthetic method of cycleanine. The synthetic method comprises the following steps: step a, mixing triethylene tetramine, water,potassium carbonate and acetone to obtain a mixture, separately adding paratoluensulfonyl chloride into the mixture in different batches, and synthesizing a compound 2; step b, adding the compound 2and 1,2-dibromoethane into a solvent, and synthesizing a compound 3 in the presence of alkaline metal carbonate; step c, adding water and sulfuric acid into the compound 3, adding ethanol into a reaction product, precipitating, discharging, centrifuging, collecting a solid product, adding water and active carbon into the solid product, stirring, decoloring, centrifuging, collecting filtrate, adding hydrochloric acid, perfor ming salting-out crystallization, precipitating, discharging, centrifuging, collecting the solid product, and obtaining a compound 4; and step d, taking the compound 4 andan alkaline substance as raw materials, synthesizing a cycleanine crude product, extracting and purifying by virtue of methylbenzene-water, and obtaining the cycleanine. The high-efficiency environment-friendly low-cost synthetic method has the advantages of low cost, high efficiency, environmental friendliness.

Straightforward approach to efficient oxidative DNA cleaving agents based on Cu(ii) complexes of heterosubstituted cyclens

The Cu(ii) complexes of cyclen and two of its heterosubstituted analogues were shown to be efficient oxidative DNA cleavers. The reactivity strongly depends on the heteroatom inserted into the macrocycle (O > S > N). The Royal Society of Chemistry 2013.

Synthesis and characterization of binuclear Zn(II)-cyclen complexes bridged by α,ω-bis(4-methylphenoxy) alkanes

A series of novel α,ω-bis(4-methylphenoxy) alkane functionalized cyclen ligands were synthesized by the nucleophilic substitution reaction of 1,4,7-tris(tert-butyloxycarbonyl)-1,4,7,10-tetraazacyclododecane and α,ω-bis(4-bromomethylphenoxy) alkanes. The corresponding dimeric Zn(II)-cyclen complexes were obtained by reaction of these ligands with Zn(ClO4)2·6H2O. Ligands and complexes were characterized by FT-IR, 1H NMR, and elemental analysis. Springer Science+Business Media B.V. 2012.

A copper-cyclen coordination complex associated with a polyoxometalate anion: Synthesis, crystal structure and electrochemistry of [Cu(cyclen)(MeCN)] [W6O19]

The reaction between Cu(NO3)2?3H2O and a tetra-aza macrocycle, more specifically, cyclen in 1:1 MeCN-MeOH solvent mixture forms a Cu2+-cyclen coordination complex in situ, that has been reacted with an isopolyanion [W6O19]2- in a slow diffusion technique, resulting in the isolation of an ion-pair solid [Cu(cyclen)(MeCN)][W6O19] (1). Single crystal structural investigation on 1 shows a square pyramidal geometry around the metal centre (copper ion) with an axially bound MeCN solvent molecule. The title compound 1 is the first crystallographically characterized ion-pair compound, in which a transition metal coordination complex of a tetra-aza-crown ether (cyclen) has been associated with a polyoxometalate cluster anion. This communication deals with synthesis, spectroscopic, structural and electrochemical analyses of compound 1.

New synthetic routes for 1-benzyl-1,4,7,10-tetraazacyclododecane and 1,4,7,10-tetraazacyclododecane-1-acetic acid ethyl ester, important starting materials for metal-coded DOTA-based affinity tags

Two improved routes to synthesize 1-benzyl-1,4,7,10-tetraazacyclododecane (6) and 1,4,7,10-tetraazacyclododecane-1-acetic acid ethyl ester (11) are described as well as the synthesis of 1-{2-[4-(maleimido-N-propylacetamidobutyl) amino]-2-oxoethyl}-1,4,7,10-tetraazacyclododecane-4,7,10-triacetic acid (17) and its Y, Ho, Tm, and Lu complexes. The 1H and 13C NMR spectra of the new compounds as well as the single crystal X-ray structure analyses of the intermediates 4-benzyl-1,7-bis(p-toluenesulfonyl) diethylenetriamine (3) and 1,4,7-tris(p-toluenesulfonyl)diethylenetriamine (7) are reported and discussed. The rare earth complexes of 17 have been characterized by 1H NMR spectroscopy and MALDI-TOF mass spectrometry.

Synthesis, characterisation and anti-protozoal activity of carbamate-derived polyazamacrocycles

A short, highly efficient approach for the synthesis of a novel class of polyazamacrocycles containing N-functionalised carbamate side-chains has been developed. The key steps involved a phase-transfer mediated macrocyclisation to form the ring system as well as a tin-catalysed reaction with isocyanates to introduce the carbamate side-chains. X-Ray crystallography confirmed successful formation of the 1,4,7,10-tetraazacyclododecane ring and N-functionalisation of all the amine centres. Preliminary testing of the biological activity of the compounds revealed significant anti-parasitic activity against bloodstream form African trypanosomes. The Royal Society of Chemistry.

Microwave-assisted synthesis of 1,4,7,10-tetraazacyclododecane

Tosylated cyclen is synthesized by the condensation of tritosylated diethanolamine and tosylamide monosodium salt under microwave irradiation, which, on detosylation with HBr, gives cyclen dihydrobromide. X-ray crystal structure of cyclen dihydrobromide i

Convenient method for preparation of aza-crown ethers

A convenient method for the preparation of peraza crown ethers in a one-pot synthesis in the presence of KF/Al2O3 is presented. Copyright Taylor & Francis Group, LLC.